{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:22:43Z","timestamp":1791901363469,"version":"4.3.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Polydeoxyribonucleotide (PDRN) is known to enhance wound healing, but there has been no clinical trial investigating the effect of PDRN on scar prevention in surgical wounds. This study aimed to evaluate the efficacy of PDRN administration in preventing postoperative scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>In this randomized controlled trial (NCT05149118), 44 patients who underwent open thyroidectomy were randomly assigned to the PDRN treatment or untreated control group. Only patients in the treatment group received two consecutive injections of PDRN 1 and 2 days after surgery. The modified Vancouver Scar Scale (mVSS), patients' subjective symptoms, erythema index (EI), melanin index (MI), and scar height were assessed 3 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients in the treatment group had lower mVSS scores (1.619\u2009\u00b1\u20091.244 vs. 2.500\u2009\u00b1\u20091.540, respectively;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.059) and a significantly lower vascularity subscore (0.476\u2009\u00b1\u20090.512 vs. 0.900\u2009\u00b1\u20090.447, respectively;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.010) than those in the control group at the 3-month follow-up. Compared with the control group, the level of subjective symptoms, EI, and scar height were all significantly lowered in the PDRN injection group. No specific side effects related to PDRN injection were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>This is the first clinical study that demonstrated that PDRN injections rapidly decreased postsurgical wound erythema and as a result, significantly reduced both excessive scar formation and accompanying symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early postoperative injection of PDRN is an effective and safe treatment to prevent hypertrophic scars and improve scar outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2022.0025","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T06:47:04Z","timestamp":1655448424000},"page":"361-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Early Postoperative Injections of Polydeoxyribonucleotide Prevent Hypertrophic Scarring After Thyroidectomy: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-1606","authenticated-orcid":false,"given":"Bo Ri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Hyo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea."},{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-6964","authenticated-orcid":false,"given":"Woo-Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonjae","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head &amp; Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Im","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea."},{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hun","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea."},{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Won","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea."},{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.11.021"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22812"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000256"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12472"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.5.615"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006064"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2015.42.1.20"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-7397-6"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.12.026"},{"issue":"1","key":"e_1_3_5_11_2","first-page":"s2","article-title":"Mechanobiology of scarring","volume":"19","author":"Ogawa R","year":"2011","unstructured":"Ogawa R. 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