{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:45:54Z","timestamp":1773305154503,"version":"3.50.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study is to characterize breath-hold (BH)-induced oxygenation changes in diabetic foot ulcers (DFUs) and develop an oxygenation flow index (OFI) to discern nonhealing from healing DFUs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>The imaging approach utilizes an innovative BH stimulus that induces vasoconstriction and measures for altering oxygenation flow in and around the tissues of DFUs and controls. The modified Beer\u2013Lambert law was utilized to calculate hemoglobin-based spatiotemporal oxygenation maps in terms of oxygen saturation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found controls had synchronous BH-induced oxygenation changes across the dorsal (OFI: 29.0%) and plantar (OFI: 57.6%) aspects of the foot. Nonhealing DFUs, however, had less synchronous BH-induced oxygenation changes (OFI &lt;28%). In addition, two complicated healing DFU cases, or cases with underlying issues or poor long-term healing outcomes, were observed to have OFIs &lt;28%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>An OFI was developed to differentiate nonhealing DFUs from healing DFUs using a single, noncontact, near-infrared optical scanner for spatiotemporal oxygenation monitoring. The OFI has potential to provide immediate feedback on the microcirculation in DFUs, through hemoglobin-based oxygenation parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A preliminary threshold (OFI &lt;28%) could differentiate nonhealing and complicated DFUs from healing DFUs. The overall oxygenation flow pattern was less synchronous (or the OFI value reduced) in the nonwound areas of the feet that were nonhealing. In other words, the reduced OFI value (&lt;28%) in the entire foot, excluding the wound region is a possible indicator that the wound may not heal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2022.0170","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T02:01:11Z","timestamp":1681524071000},"page":"22-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a Tissue Oxygenation Flow-Based Index Toward Discerning the Healing Status in Diabetic Foot Ulcers"],"prefix":"10.1177","volume":"13","author":[{"given":"Kevin","family":"Leiva","sequence":"first","affiliation":[{"name":"Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Trinidad","sequence":"additional","affiliation":[{"name":"Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliette","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology, UM Wound Care Center, University of Miami, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zwick","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology, UM Wound Care Center, University of Miami, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Edward","family":"Levine","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology, UM Wound Care Center, University of Miami, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magaly Adelaida","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology, UM Wound Care Center, University of Miami, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadar","family":"Lev-Tov","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology, UM Wound Care Center, University of Miami, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Florida International University, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Kirsner","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology, UM Wound Care Center, University of Miami, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-5909","authenticated-orcid":false,"given":"Anuradha","family":"Godavarty","sequence":"additional","affiliation":[{"name":"Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_3_6_3_2","unstructured":"Anonymous. 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