{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:34:34Z","timestamp":1790228074478,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study is the first prospective within-patient self-controlled research seeking to investigate the safety and efficacy of 595\u2009nm pulsed-dye laser (PDL) for the treatment of cleft-lip scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>This prospective, randomized, self-controlled study is based on the clinical records of the patients who received laser-assisted treatment due to bilateral cleft-lip scars. The bilateral scars were randomly assigned to the 595\u2009nm PDL group with five consecutive sessions at 2-week intervals or control group in a blinded manner of evaluators, with subsequent follow-up for 6 months after the final treatment. Clinical efficacy and safety outcomes were evaluated by Vancouver Scar Scale (VSS), Patient Scar Assessment Questionnaire (PSAQ), and other objective evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 18 patients were included. The 595\u2009nm PDL-treated sides showed statistically significant improvement in VSS after treatment at follow-up compared with the baseline (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Interestingly, the 595\u2009nm-PDL-treated side achieved significantly better improvement in scar pigmentation and pliability (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Though there was statistically significant difference between two groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05), the gap in overall PSAQ is not obvious. And comparison by area and coloring evaluation (E\/M index) also suggests that the responses of scars to treatment by PDL were slightly improved (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>It is the first time to apply the 595nm PDL for cleft-lip scars. It would be a better choice for the early treatment of red scar with proliferative tendency after cleft-lip surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2023.0106","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T06:08:30Z","timestamp":1705990110000},"page":"322-328","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effectiveness of 595-nm Pulsed Dye Laser for the Treatment of Bilateral Cleft-Lip Scars in Asian Patients: A 6-Month Prospective, Randomized, Self-Controlled Trial"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-7711","authenticated-orcid":false,"given":"Haoshu","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Oral &amp; Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai, China."},{"name":"National Center for Stomatology, Shanghai, China."},{"name":"National Clinical Research Center for Oral Diseases, Shanghai, China."},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai, China."},{"name":"National Center for Stomatology, Shanghai, China."},{"name":"National Clinical Research Center for Oral Diseases, Shanghai, China."},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai, China."},{"name":"Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai, China."},{"name":"National Center for Stomatology, Shanghai, China."},{"name":"National Clinical Research Center for Oral Diseases, Shanghai, China."},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai, China."},{"name":"National Center for Stomatology, Shanghai, China."},{"name":"National Clinical Research Center for Oral Diseases, Shanghai, China."},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai, China."},{"name":"Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Stomatology, Shanghai Jiao Tong University, Shanghai, China."},{"name":"National Center for Stomatology, Shanghai, China."},{"name":"National Clinical Research Center for Oral Diseases, Shanghai, China."},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai, China."},{"name":"Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."},{"name":"Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; 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