{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:50:57Z","timestamp":1773305457963,"version":"3.50.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Chronic wound healing is a complex process that is still not well understood. The tryptophan (TRP)-\n                      <jats:sc>l<\/jats:sc>\n                      -kynurenine (KYN) pathway has recently been under increased scrutiny with regard to wound healing. The study applied metabolomics to elucidate the TRP-\n                      <jats:sc>l<\/jats:sc>\n                      -KYN pathway associated with wound healing in chronic venous leg ulcers (CVLUs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>This study used a longitudinal comparative design of 60 serum samples collected from 30 older adult patients with CVLUs, receiving weekly sharp debridement at a wound clinic. The serum samples were collected at baseline and week 4 (healed wounds) or week 8 (nonhealed wounds). Liquid chromatography\u2013mass spectrometry (LC-MS) metabolomics was used to analyze targeted metabolites. A Bayesian approach was used to examine robust correlations between changes in metabolite values and linear healing slope and to compare by group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age was 71.13 (\u00b19.46 years). Half of the sample were female and the minority (17%) were Black. The mean values of evaluated metabolites for the nonhealed group were consistently lower than those for the healed group. The healed group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12) had higher KYN values. Those on a healing trajectory (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 23) had lower KYN levels and higher TRP levels at baseline and over time. There was moderate support (Bayes factor = 3.70) for a negative association between change in kynurenic acid and linear healing slope (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.35, credibility intervals [CrI] = \u22120.62, \u22120.04; probability of direction [PD] = 98%). Results suggest that KYN and TRP may be markers for healing in individuals with CVLUs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>\n                      Gaining a better understanding of the associations between the TRP-\n                      <jats:sc>l<\/jats:sc>\n                      -KYN pathway and the healing of CVLUs may help to clarify the links of inflammation with the rate and success of wound healing. Biomarker development focused on the TRP-\n                      <jats:sc>l<\/jats:sc>\n                      -KYN pathway could be pursued, if the associations are further supported by focused research studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2023.0137","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T06:14:21Z","timestamp":1711001661000},"page":"494-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Tryptophan\/Kynurenine Metabolites with Healing in Chronic Venous Leg Ulcers"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-7520","authenticated-orcid":false,"given":"Junglyun","family":"Kim","sequence":"first","affiliation":[{"name":"College of Nursing, Chungnam National University, Daejeon, The Republic of Korea."},{"name":"Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Stechmiller","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Lyon","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistical Science, University of Idaho College of Science, Moscow, Idaho, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungmin C.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali R.","family":"De Carvalho","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra Lynch","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121739"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2019.0946"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000622"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2021.06.010"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13332"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2014.927312"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18276-0"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12245"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20306"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7592-1_28"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.02.008"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2MB25105A"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3426-2"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-011-0329-9"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.098"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904173"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02565"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2020.1215"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0420"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2014.03.003"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12102"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.09.018"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-023-00476-z"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21670"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2020.1355"},{"key":"e_1_3_5_29_2","article-title":"The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers","author":"Kim J","year":"2022","unstructured":"Kim J, , Stechmiller J, , Weaver M, et al. The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers. Int Wound J, 2022","journal-title":"Int Wound J"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)80021-8"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12365"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128439"},{"key":"e_1_3_5_33_2","unstructured":"Information NCfB. PubChem Compound Summary for CID 3845 Kynurenic acid. 2023 [updated 2023-05-05] Available from: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/3845."},{"key":"e_1_3_5_34_2","unstructured":"National Center for Biotechnology Information. PubChem Compound Summary for CID 5699 Xanthurenic acid. 2023 [updated 2023-05-05] Available from: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/5699."},{"key":"e_1_3_5_35_2","unstructured":"Information NCfB. PubChem Compound Summary for CID 227 Anthranilic acid. 2023 [updated 2023-05-05] Available from: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/227."},{"key":"e_1_3_5_36_2","first-page":"2","article-title":"Bayesian first aid: A package that implements Bayesian alternatives to the classical*. test functions in R","volume":"2014","author":"B\u00e5\u00e5th R","year":"2014","unstructured":"B\u00e5\u00e5th R. Bayesian first aid: A package that implements Bayesian alternatives to the classical*. test functions in R. Proceedings of useR, 2014; 2014:2.","journal-title":"Proceedings of useR"},{"key":"e_1_3_5_37_2","volume-title":"Correlation: Methods for correlation analysis (R package version 0.8. 2)","author":"Makowski D","year":"2022","unstructured":"Makowski D, , Wiernik B, , Patil I, et al. Correlation: Methods for correlation analysis (R package version 0.8. 2). CRAN; 2022."},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476572"},{"key":"e_1_3_5_39_2","unstructured":"Information NCfB. PubChem Compound Summary for CID 6305 Tryptophan. 2023 [updated 2023-05-05]. Available from: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/6305."},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.02.030"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091955"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081546"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.059"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.4960"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00681.x"}],"container-title":["Advances in Wound Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/wound.2023.0137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2023.0137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2023.0137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:22:41Z","timestamp":1773238961000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/wound.2023.0137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1089\/wound.2023.0137"],"URL":"https:\/\/doi.org\/10.1089\/wound.2023.0137","relation":{},"ISSN":["2162-1918","2162-1934"],"issn-type":[{"value":"2162-1918","type":"print"},{"value":"2162-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]}}}