{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:37:53Z","timestamp":1786361873930,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>\n                      As an essential procedure, wound care comes with acute pain, which is short but high in intensity, causing patients to fear and affecting subsequent treatment. Nitrous oxide (N\n                      <jats:sub>2<\/jats:sub>\n                      O) is used to relieve pain related to wound care; however, evidence regarding its application is conflicting. Thus, this systematic review and meta-analysis was performed to evaluate the efficacy of N\n                      <jats:sub>2<\/jats:sub>\n                      O in wound care\u2013related pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Randomized controlled trials that investigated the effect of N\n                      <jats:sub>2<\/jats:sub>\n                      O in adults undergoing wound care were systematically searched from PubMed, Embase, the Cochrane Library, Web of Science, Scopus, and ClinicalTrials.gov up to February 2023. The primary outcome was the pain score. Secondary outcomes included patients\u2019 satisfaction and side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      Through screening the 265 identified articles, seven and six studies were finally included in the systematic review and meta-analysis, respectively. Pooled analysis suggested that there was no significant difference in reducing wound care\u2013related pain between the N\n                      <jats:sub>2<\/jats:sub>\n                      O group and the control group (mean difference [MD], \u22120.02, 95% confidence interval [CI], \u22121.46, 1.42;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.98,\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 96%). Subgroup analyses indicated that there was a significant difference in favor of N\n                      <jats:sub>2<\/jats:sub>\n                      O for burns, not for ulcers, and N\n                      <jats:sub>2<\/jats:sub>\n                      O was superior to oxygen and similar to topical or intravenous anesthesia. There was no significant difference in patients\u2019 satisfaction or the incidence of side effects between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      This review suggests that N\n                      <jats:sub>2<\/jats:sub>\n                      O might be effective for pain management in patients undergoing wound care. Caution must be taken when interpreting these results due to the high risk of biased methods in the included studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2023.0211","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T06:14:37Z","timestamp":1711001677000},"page":"542-552","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Nitrous Oxide to Reduce Wound Care\u2013Related Pain in Adults: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3174-1894","authenticated-orcid":false,"given":"Ziyang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology, The 960th Hospital of People\u2019 s Liberation Army of China (PLA), Jinan, People\u2019s Republic of China."},{"name":"School of Nursing, Weifang Medical University, Weifang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The 960th Hospital of People\u2019s Liberation Army of China (PLA), Jinan, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The 960th Hospital of People\u2019 s Liberation Army of China (PLA), Jinan, People\u2019s Republic of China."},{"name":"School of Nursing, Weifang Medical University, Weifang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The 960th Hospital of People\u2019 s Liberation Army of China (PLA), Jinan, People\u2019s Republic of China."},{"name":"School of Nursing, Weifang Medical University, Weifang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The 960th Hospital of People\u2019 s Liberation Army of China (PLA), Jinan, People\u2019s Republic of China."},{"name":"School of Nursing, Weifang Medical University, Weifang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The 960th Hospital of People\u2019 s Liberation Army of China (PLA), Jinan, People\u2019s Republic of China."},{"name":"School of Nursing, Shandong First Medical University, Tai\u2019an, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The 960th Hospital of 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