{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:36:44Z","timestamp":1788478604076,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This prospective cohort study aimed to determine the relationship between serum vitamin C, D, and zinc on foot wound healing and compare time to healing in individuals who are deficient versus those who have adequate levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>One hundred adults with foot wounds were recruited from Blacktown high-risk foot service with a follow-up period of 12 months. Serum vitamin C, D, and zinc as well as routine baseline blood testing was undertaken. Wounds were measured using a three-dimensional wound camera and classified using the Wound Ischemia and Foot Infection system at regular intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Vitamin C deficiency was present in 75% of participants, 50% had vitamin D deficiency, and 38% had zinc deficiency. Diabetes was present in 91% of participants, and 50% had a history of previous amputation. Wound chronicity (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03) and toe pressures (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.04) were predictive of wound healing. Serum vitamin C, D, and zinc were not associated with significant differences in wound healing or time to wound healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>Deficiencies in vitamin C, D, and zinc were highly prevalent in participants with active foot ulceration. Wound chronicity was predictive of healing outcomes, highlighting the importance of rapid access to best practice care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This cohort had high deficiency rates of vitamin C, D, and zinc consistent with previous literature; however, there was no relationship between these deficiencies and wound healing or time to heal. Large randomized controlled trials are required to comprehensively determine if adequate levels of these nutrients improve wound healing outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:fig orientation=\"portrait\" position=\"float\">\n                        <jats:caption>\n                          <jats:p>Nada Bechara<\/jats:p>\n                        <\/jats:caption>\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" orientation=\"portrait\" position=\"float\" xlink:href=\"10.1089_wound.2024.0063-fig1.tif\"\/>\n                      <\/jats:fig>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2024.0063","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T10:58:11Z","timestamp":1719572291000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prospective Evaluation of Vitamin C, Vitamin D, and Zinc Deficiencies in Patients with Active Foot Ulceration"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-8265","authenticated-orcid":false,"given":"Nada","family":"Bechara","sequence":"first","affiliation":[{"name":"The Westmead Institute for Medical Research, Centre for Diabetes, Obesity and Endocrinology Research, The University of Sydney, Westmead, Australia."},{"name":"Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, Australia."},{"name":"Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-3023","authenticated-orcid":false,"given":"Peta","family":"Tehan","sequence":"additional","affiliation":[{"name":"Sub-faculty of Clinical and Molecular Sciences, Faculty of Medicine, Health and Nursing, Monash University, Clayton, Australia."},{"name":"School of Health Sciences, College of Health Medicine and Wellbeing, University of Newcastle, Callaghan, Australia."},{"name":"Nursing and Health Services Research, Avondale University, Avondale, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny E.","family":"Gunton","sequence":"additional","affiliation":[{"name":"The Westmead Institute for Medical Research, Centre for Diabetes, Obesity and Endocrinology Research, The University of Sydney, Westmead, Australia."},{"name":"Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2021.30.5.S38"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-016-0137-6"},{"key":"e_1_3_1_4_2","unstructured":"ACSQHC. 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