{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:00:12Z","timestamp":1789236012147,"version":"build-2803163510"},"reference-count":39,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate if treatment of diabetic wounds by copper oxide impregnated dressings (COD) is noninferior to negative pressure wound therapy (NPWT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>\n                      Following the CONSORT guidelines, patients with diabetes mellitus (type 1 or type 2) and noninfected wounds eligible for treatment with NPWT were randomized into two groups. One group received NPWT followed by standard wound care dressings, whereas the other was treated exclusively with COD. The primary outcome was wound size reduction, measured blindly using a 3D wound-imaging system. Secondary outcomes included patient and caregiver convenience (assessed\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      visual analog scores), cost, and additional wound parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      COD showed statistically significant noninferiority to NPWT in wound size reduction throughout the study (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01). The percentage of wounds that closed was 47.83% (11\/23) and 34.78% (8\/23) in the COD and NPWT arms, respectively (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05). The average time to wound closure, adjusted to potential confounders, such as gender, age, body mass index, diabetes, and smokers, was similar in both arms (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05). COD were found to be more convenient than NPWT for both patients (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and caregivers (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.003), with a significantly shorter application time (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). The COD cost was 14% of NPWT cost ($470 compared with $3,360).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>COD may be considered as the first line of treatment for diabetic foot wounds when NPWT seems indicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Using copper dressings as a first line of treatment of diabetic wounds, when NPWT is indicated, is expected to reduce health costs, improve convenience, and increase compliance without compromising the final outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/wound.2024.0273","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T10:40:05Z","timestamp":1746700805000},"page":"659-670","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"15","author":[{"given":"Eyal","family":"Melamed","sequence":"first","affiliation":[{"name":"Foot and Ankle Service, Division of Orthopedics, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihad","family":"Dabbah","sequence":"additional","affiliation":[{"name":"Foot and Ankle Service, Division of Orthopedics, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Israel","sequence":"additional","affiliation":[{"name":"Foot and Ankle Service, Division of Orthopedics, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Kan","sequence":"additional","affiliation":[{"name":"Foot and Ankle Service, Division of Orthopedics, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Pinzur","sequence":"additional","affiliation":[{"name":"Loyola University Health System, Maywood, Illinois, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohar","family":"Roth","sequence":"additional","affiliation":[{"name":"MedCu Technologies Ltd., Herzliya, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-5344","authenticated-orcid":false,"given":"Gadi","family":"Borkow","sequence":"additional","affiliation":[{"name":"MedCu Technologies Ltd., Herzliya, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2538"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/db21-1015-P"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-2476"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/0115733998229877230926073555"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_72_22"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010318.pub3"},{"key":"e_1_3_5_9_2","first-page":"165","volume-title":"Recent Advances in Wound Healing","author":"Borkow G","year":"2021","unstructured":"Borkow G, , Melamed E. Copper, an abandoned player returning to the wound healing battle. In: Recent Advances in Wound Healing. (Aghaei S. ed.) IntechOpen London: 5 Princes Gate Court, London, SW7 2QJ, UK; 2021; pp. 165\u2013184."},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129260"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.02.012"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071982"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2012.665970"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.07.014"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15080978"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.02.033"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13186"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.10.009"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00803-1"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008200903288431"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.03.018"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-007-0244-1"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0942-x"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02718-8"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep33783"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000517194"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00573.x"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.2174\/187231312801254723"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57030296"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101129"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.26502\/acmcr.96550504"},{"issue":"3","key":"e_1_3_5_32_2","first-page":"466","article-title":"Copper dressings to the wound rescue after everything else failed: Case report","volume":"6","author":"Weitman CC","year":"2022","unstructured":"Weitman CC, , Roth T, , Borkow G. Copper dressings to the wound rescue after everything else failed: Case report. Arch Clin Med Case Rep, 2022; 6(3):466\u2013473.","journal-title":"Arch Clin Med Case Rep"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1816"},{"key":"e_1_3_5_34_2","volume-title":"Recent Advances in Wound Healing","author":"Borkow G","year":"2021","unstructured":"Borkow G, , Melamed E. Copper, an abandoned player returning to the wound healing battle. In: Recent Advances in Wound Healing. (Shahin A. ed.) IntechOpen: London; 2021."},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.12.788"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/microbiolres13030029"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/microbiolres15040158"},{"key":"e_1_3_5_38_2","volume-title":"Introduction to Statistical Analysis","author":"Dixon WJ","year":"1983","unstructured":"Dixon WJ, , Massey FJ. Introduction to Statistical Analysis. McGraw-Hill; 1983."},{"key":"e_1_3_5_39_2","volume-title":"Applied Analysis of Variance in Behavioral Science","author":"O\u2019Brien RG","year":"1993","unstructured":"O\u2019Brien RG, , Muller KE. Applied Analysis of Variance in Behavioral Science. Marcel Dekker: New York; 1993."},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001211"}],"container-title":["Advances in Wound Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/wound.2024.0273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2024.0273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/wound.2024.0273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:18:17Z","timestamp":1784157497000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/wound.2024.0273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1089\/wound.2024.0273"],"URL":"https:\/\/doi.org\/10.1089\/wound.2024.0273","relation":{},"ISSN":["2162-1918","2162-1934"],"issn-type":[{"value":"2162-1918","type":"print"},{"value":"2162-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}