{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:45:11Z","timestamp":1773308711486,"version":"3.50.1"},"reference-count":52,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Zebrafish"],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fibrodysplasia Ossificans Progressiva (FOP) is a rare, autosomal dominant genetic disorder in humans characterized by the gradual ossification of fibrous tissues, including skeletal muscle, tendons, and ligaments. In humans, mutations in the Type I BMP\/TGF\u03b2 family member receptor gene,\n                    <jats:italic toggle=\"yes\">ACVR1<\/jats:italic>\n                    , are associated with FOP. Zebrafish\n                    <jats:italic toggle=\"yes\">acvr1l<\/jats:italic>\n                    , previously known as\n                    <jats:italic toggle=\"yes\">alk8<\/jats:italic>\n                    , is the functional ortholog of human\n                    <jats:italic toggle=\"yes\">ACVR1<\/jats:italic>\n                    . We previously created and characterized the first adult zebrafish model for FOP by generating animals harboring heat shock-inducible mCherry-tagged constitutively active Acvr1l (Q204D). Since injury is a known trigger for heterotopic ossification (HO) development in human FOP patients, in this study, we investigated several injury models in Acvr1l\n                    <jats:sup>Q204D<\/jats:sup>\n                    -expressing zebrafish and the subsequent formation of HO. We performed studies of Activin A injection, cardiotoxin (CTX) injection, and caudal fin clip injury. We found that none of these methods resulted in HO formation at the site of injury. However, some of the cardiotoxin-injected and caudal fin-clipped animals did exhibit HO at distant sites, including the body cavity and along the spine. We describe these results in the context of new and exciting reports on FOP, and discuss future studies to better understand the etiology and progression of this disease.\n                  <\/jats:p>","DOI":"10.1089\/zeb.2018.1611","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T10:44:19Z","timestamp":1536144259000},"page":"536-545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Injury of Adult Zebrafish Expressing Acvr1l\n                    <sup>Q204D<\/sup>\n                    Does Not Result in Heterotopic Ossification"],"prefix":"10.1177","volume":"15","author":[{"given":"Melissa","family":"LaBonty","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine"},{"name":"Tufts University School of Dental Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Pray","sequence":"additional","affiliation":[{"name":"Tufts University School of Dental Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela C.","family":"Yelick","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine"},{"name":"Tufts University School of Dental Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199302000-00009"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.11.007"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1232-5"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-80"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010280"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20868"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.122"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70408-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000129557.38803.26"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.26464"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199801000-00005"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1385\/BMM:3:3-4:189"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2515"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf1090"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02872-2"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200702000-00017"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.01.008"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.08.023"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1637"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4358"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93521"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510540112"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0576"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2334"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24606"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2016.1398"},{"key":"e_1_3_4_28_2","unstructured":"Westerfield M: The Zebrafish Book. 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