{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:43:32Z","timestamp":1773308612117,"version":"3.50.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Zebrafish"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Schinus terebinthifolius<\/jats:italic>\n                    Raddi (Anacardiaceae) is popularly known in Brazil as\n                    <jats:italic toggle=\"yes\">aroeira-da-praia<\/jats:italic>\n                    and has pharmacological use as an astringent, antidiarrheal, anti-inflammatory, depurative, diuretic, and antifebrile agent. Although the neuropathic antinociceptive potential of\n                    <jats:italic toggle=\"yes\">S. terebinthifolius<\/jats:italic>\n                    fruits has already been investigated, this study is the first one to analyze the acute antinociceptive effect of the essential oil of\n                    <jats:italic toggle=\"yes\">S. terebinthifolius<\/jats:italic>\n                    (female) leaves (EOFSt) on adult zebrafish. EOFSt was submitted to antioxidant activity evaluation by two methods (ferrous ion-chelating capacity [FIC] and \u03b2-carotene). The animals (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096\/group) were treated orally (20\u2009\u03bcL) with EOFSt (0.1, 0.5, or 1.0\u2009mg\/mL) or vehicle (0.9% sodium chloride [NaCl]; 20\u2009\u03bcL), and submitted to nociception (formalin, cinnamaldehyde, capsaicin, glutamate, acidic saline, and hypertonic saline). Possible neuromodulation mechanisms, as well motor alterations and toxicity were also evaluated. In the FIC assay, EOFSt showed ferrous ion-chelating capacity in \u223c40% to 90%. Regarding the \u03b2-carotene bleaching assay, EOFSt showed inhibition in a 58% to 80% range. Oral administration of EOFSt showed no acute toxicity and did not alter the locomotor system of aZF, and reduced the nociceptive behavior in all tested models. These effects of EOFSt were significantly similar to those of morphine, used as a positive control. The antinociceptive effect of EOFSt was inhibited by naloxone, L-NAME, ketamine, camphor, ruthenium red, and amiloride. The antinociceptive effect of the EOFSt cornea was inhibited by capsazepine. EOFSt has the pharmacological potential for acute pain treatment and this effect is modulated by the opioid system, NMDA receptors, and transient receptor potential ankyrin 1 (TRPA1), transient receptor potential vanilloid 1 (TRPV1), and acid-sensing ion channels. The EOFSt also has the pharmacological potential for corneal pain treatment and this effect is modulated by the TRPV1 channel.\n                  <\/jats:p>","DOI":"10.1089\/zeb.2019.1809","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T15:36:50Z","timestamp":1582817810000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Antinociceptive Effect of the Essential Oil of\n                    <i>Schinus terebinthifolius<\/i>\n                    (female) Leaves on Adult Zebrafish (\n                    <i>Danio rerio<\/i>\n                    )"],"prefix":"10.1177","volume":"17","author":[{"given":"Maria da Concei\u00e7\u00e3o L.","family":"Lima","sequence":"first","affiliation":[{"name":"Laboratory of Natural Product Bioprospecting and Biotechnology (LBPNB), Ceara State University, Department of Chemistry, Campus CECITEC, Tau\u00e1, 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Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana R.","family":"Campos","sequence":"additional","affiliation":[{"name":"Experimental Biology Nucleus (NUBEX), University of Fortaleza, Fortaleza, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila T.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tigressa Helena S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Science and Technology Center\u2014Chemistry Course, State University of Vale do Acarau, Sobral, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Geysillene C.","family":"Matos","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina C.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Marine Natural Products, Department of Fishing Engineering, Federal University of Ceara, Fortaleza, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia B.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Institute of Exact and Nature Sciences, Biological Sciences Course, University of the Integration of Afro-Brazilian Lusophony, Reden\u00e7\u00e3o, Cear\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Saker-Sampaio","sequence":"additional","affiliation":[{"name":"Laboratory of Marine Natural Products, Department of Fishing Engineering, Federal University of Ceara, Fortaleza, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Integrated Laboratory of Biomolecules (LIBS), Federal University of Ceara, Department of Pathology and Legal Medicine, Fortaleza, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson H.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Integrated Laboratory of Biomolecules (LIBS), Federal University of Ceara, Department of Pathology and Legal Medicine, Fortaleza, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lcio Silva","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato, Brazil."},{"name":"Science and Technology Center\u2014Chemistry Course, State University of Vale do Acarau, Sobral, 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