{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:04:25Z","timestamp":1773324265434,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>\n                    Resistance to carbapenems is emerging, and it is a great problem to therapeutics. Three isolates of\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    from a Portuguese hospital identified in urine and sputum, in 1995, presented\n         a high-level resistance to imipenem (&gt;32 mg\/L). Afterward, one isolate of\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    recovered from urine of an ambulatory patient in 1998 showed high resistance to imipenem and meropenem.\n         The resistance to carbapenems in these strains was associated with the production of a class B\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -lactamase, as was demonstrated by imipenem hydrolysis and inhibition by EDTA. Using primers described\n         for\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>IMP<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM<\/jats:sub>\n                    , the amplification of the latter was observed in all isolates and a VIM-2 metallo-enzyme was identified. The pulsed-field gel electrophoresis (PFGE)\n         patterns of these isolates were indistinguishable, suggesting dissemination to the community of this VIM-2 producer.\n                  <\/jats:p>","DOI":"10.1089\/107662902760190635","type":"journal-article","created":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T13:59:54Z","timestamp":1033394394000},"page":"93-97","source":"Crossref","is-referenced-by-count":50,"title":["Metallo-\n                    <i>\u03b2<\/i>\n                    -Lactamase VIM-2 in Clinical Isolates of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    from Portugal"],"prefix":"10.1177","volume":"8","author":[{"given":"Olga","family":"Cardoso","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia C.E.F. da Faculdade de Farm\u00e1cia da Universidade de Coimbra, 3030 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia C.E.F. da Faculdade de Farm\u00e1cia da Universidade de Coimbra, 3030 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia de Faculdade de Farm\u00e1cia da Universidade do Porto, 4050 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Carlos","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia de Faculdade de Farm\u00e1cia da Universidade do Porto, 4050 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia da Faculdade de Farm\u00e1cia da Universidade de Lisboa, 1600-083 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa Vieira","family":"Peixe","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia de Faculdade de Farm\u00e1cia da Universidade do Porto, 4050 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,6]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/107662902760190635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/107662902760190635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:14:01Z","timestamp":1770747241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/107662902760190635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1089\/107662902760190635"],"URL":"https:\/\/doi.org\/10.1089\/107662902760190635","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}