{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:19:19Z","timestamp":1777378759426,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Human Retroviruses"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>\n                    Chronic hepatitis C affects one-third of HIV\n                    <jats:sup>+<\/jats:sup>\n                    patients worldwide. High ribavirin (RBV) exposure is crucial to maximize the response to hepatitis C therapy in this population, although it may increase the risk for hemolytic anemia. PERICO is a prospective multicenter trial in which HIV\/HCV-coinfected patients are randomized to receive peginterferon (pegIFN) alfa-2a 180\u2009\u03bcg\/week plus either weight-based RBV (1000\u20131200\u2009mg\/day) or RBV 2000\u2009mg\/day, the latest along with erythropoietin alfa (EPO) 30,000\u2009IU\/week from the first day until week 4. A total of 149 patients were assessed in a planned interim analysis at week 4. In both arms, 22% of patients achieved negative HCV-RNA (rapid virological response, RVR). Multivariate analysis [OR (IC 95%),\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    ] showed that factors associated with RVR were HCV genotypes 2\/3 vs. 1\/4 [20 (5\u2013100), &lt;0.01] and baseline HCV-RNA [0.16 (0.07\u20130.37) per log IU\/ml, &lt;0.01]. The occurrence of severe anemia (hemoglobin &lt;10\u2009g\/dl) did not differ when comparing RBV vs. high RBV\u2009+\u2009EPO (7% vs. 3%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.4). Moreover, RBV plasma trough levels were comparable at week 4 (1.9 vs. 2.4\u2009\u03bcg\/ml;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.2). Use of high RBV doses with preemptive EPO during the first 4 weeks of hepatitis C therapy is safe, but fails to enhance significantly RBV plasma exposure and RVR rates. Extensive intraerythrocyte accumulation of RBV following boosted production of red blood cells by EPO could explain these findings.\n                  <\/jats:p>","DOI":"10.1089\/aid.2009.0120","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T19:40:18Z","timestamp":1270755618000},"page":"419-424","source":"Crossref","is-referenced-by-count":6,"title":["Preemptive Erythropoietin Plus High Ribavirin Doses to Increase Rapid Virological Responses in HIV Patients Treated for Chronic Hepatitis C"],"prefix":"10.1177","volume":"26","author":[{"given":"Eugenia","family":"Vispo","sequence":"first","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}]},{"given":"Pablo","family":"Labarga","sequence":"additional","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}]},{"given":"Josep M.","family":"Guardiola","sequence":"additional","affiliation":[{"name":"Hospital de Sant 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III","place":["Spain"]}]},{"given":"Sonia","family":"Rodriguez-Novoa","sequence":"additional","affiliation":[{"name":"Hospital Carlos III","place":["Spain"]}]},{"given":"Vincent","family":"Soriano","sequence":"additional","affiliation":[{"name":"Hospital Carlos 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