{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:47:17Z","timestamp":1774972037331,"version":"3.50.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medicinal Food"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Cymbopogon citratus<\/jats:italic>\n                    , an herb known worldwide as lemongrass, is widely consumed as an aromatic drink, and its fresh and dried leaves are currently used in traditional cuisine. However, little is known about the mechanism of action of\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    , namely, the anti-inflammatory effects of its dietary components. Because nitric oxide (NO), produced in large quantities by activated inflammatory cells, has been demonstrated to be involved in the pathogenesis of acute and chronic inflammation, we evaluated the effects of the infusion of dried leaves from\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    , as well as its polyphenolic fractions\u2014flavonoid-, tannin-, and phenolic acid-rich fractions (FF, TF, and PAF, respectively)\u2014on the NO production induced by lipopolysaccharide (LPS) in a skin-derived dendritic cell line (FSDC).\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    infusion significantly inhibited the LPS-induced NO production and inducible NO synthase (iNOS) protein expression. All the polyphenolic fractions tested also reduced the iNOS protein levels and NO production stimulated by LPS in FSDC cells, without affecting cell viability, with the strongest effects being observed for the fractions with mono- and polymeric flavonoids (FF and TF, respectively). Our results also indicated that the anti-inflammatory properties of FF are mainly due to luteolin glycosides. In conclusion,\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    has NO scavenging activity and inhibits iNOS expression and should be explored for the treatment of inflammatory diseases, in particular of the gastrointestinal tract.\n                  <\/jats:p>","DOI":"10.1089\/jmf.2009.0115","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T14:28:46Z","timestamp":1272896926000},"page":"681-690","source":"Crossref","is-referenced-by-count":71,"title":["Anti-Inflammatory Activity of\n                    <i>Cymbopogon citratus<\/i>\n                    Leaf Infusion in Lipopolysaccharide-Stimulated Dendritic Cells: Contribution of the Polyphenols"],"prefix":"10.1177","volume":"13","author":[{"given":"Artur","family":"Figueirinha","sequence":"first","affiliation":[{"name":"Universidade de Coimbra","place":["Portugal"]},{"name":"Instituto Polit\u00e9cnico de Viseu","place":["Portugal"]}]},{"given":"Maria Teresa","family":"Cruz","sequence":"additional","affiliation":[{"name":"Universidade de Coimbra","place":["Portugal"]},{"name":"Universidade de Coimbra","place":["Portugal"]}]},{"given":"Vera","family":"Francisco","sequence":"additional","affiliation":[{"name":"Universidade de Coimbra","place":["Portugal"]},{"name":"Universidade de Coimbra","place":["Portugal"]}]},{"given":"M. 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