{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:11:01Z","timestamp":1770941461030,"version":"3.50.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>\n                    A screening of antimicrobial resistance and its genetic determinants has been performed on 300\n                    <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    isolates collected during 2004\u20132008 from human infections in Spain.\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium and\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Enteritidis were the major serotypes, which were found with similar frequencies covering 80% of the bacterial collection.\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium isolates frequently shared low susceptibility to antimicrobials of the penta-resistance phenotype (ACSSuT) and\/or cephalosporin resistance. The ACSSuT profile was found closely linked to\n                    <jats:italic toggle=\"yes\">int1<\/jats:italic>\n                    -associated gene cassettes, with major elements carrying DNA fragments of 1.0\u2009Kb (\n                    <jats:italic toggle=\"yes\">aadA2<\/jats:italic>\n                    gene) plus 1.2\u2009Kb (\n                    <jats:italic toggle=\"yes\">blaPSE<\/jats:italic>\n                    -1 gene) or 2.0\u2009Kb (\n                    <jats:italic toggle=\"yes\">aadA1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">blaOXA<\/jats:italic>\n                    -1 genes). Among these, ACSSuT and cephalosporin resistances were associated in\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium isolates expressing the\n                    <jats:italic toggle=\"yes\">blaOXA<\/jats:italic>\n                    gene. \u03b2-lactamase activities were also detected from isolates carrying\n                    <jats:italic toggle=\"yes\">blaTEM<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">blaCMY<\/jats:italic>\n                    , or\n                    <jats:italic toggle=\"yes\">blaSHV<\/jats:italic>\n                    , although only the two last genes expressed extended-spectrum \u03b2-lactamases. The clonal analysis of\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    strains suggests that both horizontal and vertical transfer mechanisms are involved in the wide dissemination of their antimicrobial resistance.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2012.0261","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T12:21:27Z","timestamp":1370434887000},"page":"384-391","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by\n                    <i>int1-<\/i>\n                    Associated Elements in Nontyphoidal\n                    <i>Salmonella enterica<\/i>\n                    from Human Infections in Spain"],"prefix":"10.1177","volume":"19","author":[{"given":"Maria Jorge","family":"Campos","sequence":"first","affiliation":[{"name":"Universidad de Extremadura","place":["Spain"]},{"name":"Instituto Polit\u00e9cnico de Leiria (IPL)","place":["Portugal"]}]},{"given":"Gonzalo","family":"Palomo","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura","place":["Spain"]}]},{"given":"Lorena","family":"Horme\u00f1o","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura","place":["Spain"]}]},{"given":"Mar\u00eda","family":"Ugarte","sequence":"additional","affiliation":[{"name":"Universidad Complutense de Madrid","place":["Spain"]}]},{"given":"Mar\u00eda Concepci\u00f3n","family":"Porrero","sequence":"additional","affiliation":[{"name":"Universidad Complutense de Madrid","place":["Spain"]}]},{"given":"Silvia","family":"Herrera-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Salud Carlos III","place":["Spain"]}]},{"given":"Santiago","family":"Vadillo","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura","place":["Spain"]}]},{"given":"Segundo","family":"P\u00edriz","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura","place":["Spain"]}]},{"given":"Alberto","family":"Quesada","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura","place":["Spain"]}]}],"member":"179","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S0022172400056187","article-title":"Bacteriophage-typing designations of Salmonella typhimurium","volume":"78","author":"Anderson E.S.","year":"1977","unstructured":"Anderson E.S., , Ward L.R., , Desaxe M.J., , Desa J.D.H. 1977. Bacteriophage-typing designations of Salmonella typhimurium. J. Hyg. (Lond.), 78:297\u2013300.","journal-title":"J. Hyg. (Lond.)"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.12.029"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.19.5725-5732.2001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.10.3156-3163.2002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01009-09"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2001122"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2005.03.018"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.1.1-7.2004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.3.315"},{"key":"e_1_3_3_11_2","volume-title":"In Clinical laboratory testing and in vitro diagnostic test systems\u2014Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices","author":"DIN EN ISO 20776\u20131","year":"2006","unstructured":"DIN EN ISO 20776\u20131. 2006. Part 1: Reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases. In Clinical laboratory testing and in vitro diagnostic test systems\u2014Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices. Deutsches Institut f\u00fcr Normung: Berlin, Germany."},{"key":"e_1_3_3_12_2","first-page":"1658","article-title":"The Community Summary Report on antimicrobial resistance in zoonotic and indicator bacteria from animals and food in the European Union in 2008","volume":"1","author":"EFSA","year":"2010","unstructured":"EFSA. 2010. The Community Summary Report on antimicrobial resistance in zoonotic and indicator bacteria from animals and food in the European Union in 2008. EFSA J, 1:1658.","journal-title":"EFSA J"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1128\/AAC.45.1.88-95.2001","article-title":"Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa","volume":"45","author":"Essack S.Y.","year":"2001","unstructured":"Essack S.Y., , Hall L.M.C., , Pillay D.G., , McFadyen M.L., , Livermore D.M. 2001. Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa. Antimicrob. Agents Chemother., 45:88\u201395.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_14_2","unstructured":"European Commitee on Antimicrobial Susceptibility Testing (EUCAST). 2013. Antimicrobial wild type distributions of microorganisms. MIC- and Inhibition zone diameter distributions of microorganisms without and with resistance mechanisms. EUCAST version 5.13. www.eucast.org\/mic_distributions. 2012 December 20(Online.)"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1203.050854"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp361"},{"key":"e_1_3_3_17_2","first-page":"1","volume-title":"Antimicrobial Resistance in Bacteria of Animal Origin","author":"Guardabassi L.","year":"2006","unstructured":"Guardabassi L., , Courvalin P. 2006. Modes of antimicrobial action and mechanisms of bacterial resistance. Aarestrup F. Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press: Washington. 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