{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:23:29Z","timestamp":1777940609569,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Few data exist on using thyrotropin alfa (recombinant human thyroid-stimulating hormone [rhTSH]) with radioiodine for thyroid remnant ablation of patients who have T4 primary tumors (invasion beyond the thyroid capsule).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A retrospective chart review protocol at nine centers in Europe was set up with special waiver of need for informed consent, along with a careful procedure to avoid selection bias when enrolling patients into the database. Data on 144 eligible patients with T4 tumors were collected (T4, N0\u20131, M0\u20131; mean age 49.7 years; 65% female; 88% papillary cancer). All had received\n                      <jats:sup>131<\/jats:sup>\n                      I remnant ablation following TSH stimulation with rhTSH or thyroid hormone withdrawal (THW) since January 2000 (rhTSH\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =74, THW\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =70). The primary endpoint was based on evaluation of diagnostic radioiodine scan thyroid bed uptake more than six months after the ablation procedure, while stimulated serum Tg was a secondary endpoint. Safety was evaluated within 30 days after rhTSH or\n                      <jats:sup>131<\/jats:sup>\n                      I.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Successful ablation judged by scan was achieved in 65\/70 (92.9%) of rhTSH and in 61\/67 (91.0%) of THW patients; the success rates were comparable, since noninferiority criteria were met. Although some patients in the initial cohort had tumor in cervical nodes and metastases, considering all evaluable patients regardless of various serum anti-Tg antibody assessments, the stimulated Tg was &lt;2\u2009ng\/mL in 48\/70 (68.6%) and 39\/67 (58.2%) in rhTSH and THW groups respectively; if patients with anti-Tg antibody levels &gt;30\u2009IU\/mL were excluded, the stimulated Tg was &lt;2\u2009ng\/mL in 42\/62 (67.7%) and 37\/64 (57.8%) respectively. No serious adverse events occurred within the 30-day window after ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Use of rhTSH as preparation for thyroid remnant ablation in patients with T4 primary tumors achieved a rate of ablation success that was high and noninferior to the rate seen after THW, and rhTSH was well tolerated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2013.0157","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T18:15:20Z","timestamp":1379355320000},"page":"480-487","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["High-Risk Patients with Differentiated Thyroid Cancer T4 Primary Tumors Achieve Remnant Ablation Equally Well Using rhTSH or Thyroid Hormone Withdrawal"],"prefix":"10.1177","volume":"24","author":[{"given":"Peter","family":"Bartenstein","sequence":"first","affiliation":[{"name":"University of Munich","place":["Germany"]}]},{"given":"Elisa Caballero","family":"Calabuig","sequence":"additional","affiliation":[{"name":"University Hospital Dr. Peset","place":["Spain"]}]},{"given":"Carlo Ludovico","family":"Maini","sequence":"additional","affiliation":[{"name":"Regina Elena National Cancer Institute","place":["Italy"]}]},{"given":"Renzo","family":"Mazzarotto","sequence":"additional","affiliation":[{"name":"S. Orsola-Malpighi Hospital","place":["Italy"]}]},{"given":"M. Angustias","family":"Muros de Fuentes","sequence":"additional","affiliation":[{"name":"Virgen de las Nieves University Hospital","place":["Spain"]}]},{"given":"Thorsten","family":"Petrich","sequence":"additional","affiliation":[{"name":"Hannover University School of Medicine","place":["Germany"]}]},{"given":"Fernando Jos\u00e9 Cravo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Portuguese Institute of Oncology of Coimbra Francisco Gentil","place":["Portugal"]}]},{"given":"Juan Antonio","family":"Vallejo Casas","sequence":"additional","affiliation":[{"name":"University Hospital Reina Sof\u00eda de C\u00f3rdoba","place":["Spain"]}]},{"given":"Federica","family":"Vianello","sequence":"additional","affiliation":[{"name":"Institute of Oncology Veneto-IRCCS","place":["Italy"]}]},{"given":"Michela","family":"Basso","sequence":"additional","affiliation":[{"name":"Institute of Oncology Veneto-IRCCS","place":["Italy"]}]},{"given":"Marcelino G\u00f3mez","family":"Balaguer","sequence":"additional","affiliation":[{"name":"University Hospital Dr. Peset","place":["Spain"]}]},{"given":"Alexander","family":"Haug","sequence":"additional","affiliation":[{"name":"University of Munich","place":["Germany"]}]},{"given":"Fabio","family":"Monari","sequence":"additional","affiliation":[{"name":"S. Orsola-Malpighi Hospital","place":["Italy"]}]},{"given":"Raquel S\u00e1nchez","family":"Va\u0148\u00f3","sequence":"additional","affiliation":[{"name":"University Hospital Dr. Peset","place":["Spain"]}]},{"given":"Rosa","family":"Sciuto","sequence":"additional","affiliation":[{"name":"Regina Elena National Cancer Institute","place":["Italy"]}]},{"given":"James","family":"Magner","sequence":"additional","affiliation":[{"name":"Genzyme"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709253371304"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.11.6094"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2064"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1651"},{"key":"e_1_3_3_6_2","first-page":"648","article-title":"Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH or hormone withdrawal","volume":"47","author":"H\u00e4nscheid H","year":"2006","unstructured":"H\u00e4nscheid H, , Lassmann M, , Luster M, , Thomas SR, , Pacini F, , Ceccarelli C, , Ladenson PW, , Wahl RL, , Schlumberger M, , Ricard M, , Driedger A, , Kloos RT, , Sherman SI, , Haugen BR, , Carriere V, , Corone C, , Reiners C. 2006. Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH or hormone withdrawal. J Nucl Med, 47:648\u2013654.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0754-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.052464"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.050591"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e32834863b0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.049072"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0401"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0183"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108586"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109589"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2013.0157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2013.0157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2013.0157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:55:20Z","timestamp":1777701320000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2013.0157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1089\/thy.2013.0157"],"URL":"https:\/\/doi.org\/10.1089\/thy.2013.0157","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}