{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:48:40Z","timestamp":1779374920734,"version":"3.53.1"},"reference-count":40,"publisher":"American Mathematical Society (AMS)","issue":"275","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"am","delay-in-days":365,"URL":"https:\/\/www.ams.org\/publications\/copyright-and-permissions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Math. Comp."],"abstract":"<p>\n                    The Cable equation has been one of the most fundamental equations for modeling neuronal dynamics. In this paper, we consider the numerical solution of the fractional Cable equation, which is a generalization of the classical Cable equation by taking into account the anomalous diffusion in the movement of the ions in neuronal system. A schema combining a finite difference approach in the time direction and a spectral method in the space direction is proposed and analyzed. The main contribution of this work is threefold: 1) We construct a finite difference\/Legendre spectral schema for discretization of the fractional Cable equation. 2) We give a detailed analysis of the proposed schema by providing some stability and error estimates. Based on this analysis, the convergence of the method is rigourously established. We prove that the overall schema is unconditionally stable, and the numerical solution converges to the exact one with order\n                    <inline-formula content-type=\"math\/mathml\">\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"upper O left-parenthesis white up pointing triangle t Superscript 2 minus max left-brace right-brace comma alpha comma beta Baseline plus white up pointing triangle t Superscript negative 1 Baseline upper N Superscript negative m Baseline right-parenthesis\">\n                        <mml:semantics>\n                          <mml:mrow>\n                            <mml:mi>O<\/mml:mi>\n                            <mml:mo stretchy=\"false\">(<\/mml:mo>\n                            <mml:mi mathvariant=\"normal\">\n                              \u25b3\n                              \n                            <\/mml:mi>\n                            <mml:msup>\n                              <mml:mi>t<\/mml:mi>\n                              <mml:mrow class=\"MJX-TeXAtom-ORD\">\n                                <mml:mn>2<\/mml:mn>\n                                <mml:mo>\n                                  \u2212\n                                  \n                                <\/mml:mo>\n                                <mml:mo movablelimits=\"true\" form=\"prefix\">max<\/mml:mo>\n                                <mml:mo fence=\"false\" stretchy=\"false\">{<\/mml:mo>\n                                <mml:mi>\n                                  \u03b1\n                                  \n                                <\/mml:mi>\n                                <mml:mo>,<\/mml:mo>\n                                <mml:mi>\n                                  \u03b2\n                                  \n                                <\/mml:mi>\n                                <mml:mo fence=\"false\" stretchy=\"false\">}<\/mml:mo>\n                              <\/mml:mrow>\n                            <\/mml:msup>\n                            <mml:mo>+<\/mml:mo>\n                            <mml:mi mathvariant=\"normal\">\n                              \u25b3\n                              \n                            <\/mml:mi>\n                            <mml:msup>\n                              <mml:mi>t<\/mml:mi>\n                              <mml:mrow class=\"MJX-TeXAtom-ORD\">\n                                <mml:mo>\n                                  \u2212\n                                  \n                                <\/mml:mo>\n                                <mml:mn>1<\/mml:mn>\n                              <\/mml:mrow>\n                            <\/mml:msup>\n                            <mml:msup>\n                              <mml:mi>N<\/mml:mi>\n                              <mml:mrow class=\"MJX-TeXAtom-ORD\">\n                                <mml:mo>\n                                  \u2212\n                                  \n                                <\/mml:mo>\n                                <mml:mi>m<\/mml:mi>\n                              <\/mml:mrow>\n                            <\/mml:msup>\n                            <mml:mo stretchy=\"false\">)<\/mml:mo>\n                          <\/mml:mrow>\n                          <mml:annotation encoding=\"application\/x-tex\">O(\\triangle t^{2-\\max \\{\\alpha ,\\beta \\}}+ \\triangle t^{-1}N^{-m})<\/mml:annotation>\n                        <\/mml:semantics>\n                      <\/mml:math>\n                    <\/inline-formula>\n                    , where\n                    <inline-formula content-type=\"math\/mathml\">\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"white up pointing triangle t comma upper N\">\n                        <mml:semantics>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">\n                              \u25b3\n                              \n                            <\/mml:mi>\n                            <mml:mi>t<\/mml:mi>\n                            <mml:mo>,<\/mml:mo>\n                            <mml:mi>N<\/mml:mi>\n                          <\/mml:mrow>\n                          <mml:annotation encoding=\"application\/x-tex\">\\triangle t,N<\/mml:annotation>\n                        <\/mml:semantics>\n                      <\/mml:math>\n                    <\/inline-formula>\n                    and\n                    <inline-formula content-type=\"math\/mathml\">\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"m\">\n                        <mml:semantics>\n                          <mml:mi>m<\/mml:mi>\n                          <mml:annotation encoding=\"application\/x-tex\">m<\/mml:annotation>\n                        <\/mml:semantics>\n                      <\/mml:math>\n                    <\/inline-formula>\n                    are respectively the time step size, polynomial degree, and regularity in the space variable of the exact solution.\n                    <inline-formula content-type=\"math\/mathml\">\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"alpha\">\n                        <mml:semantics>\n                          <mml:mi>\n                            \u03b1\n                            \n                          <\/mml:mi>\n                          <mml:annotation encoding=\"application\/x-tex\">\\alpha<\/mml:annotation>\n                        <\/mml:semantics>\n                      <\/mml:math>\n                    <\/inline-formula>\n                    and\n                    <inline-formula content-type=\"math\/mathml\">\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"beta\">\n                        <mml:semantics>\n                          <mml:mi>\n                            \u03b2\n                            \n                          <\/mml:mi>\n                          <mml:annotation encoding=\"application\/x-tex\">\\beta<\/mml:annotation>\n                        <\/mml:semantics>\n                      <\/mml:math>\n                    <\/inline-formula>\n                    are two different exponents between 0 and 1 involved in the fractional derivatives. 3) Finally, some numerical experiments are carried out to support the theoretical claims.\n                  <\/p>","DOI":"10.1090\/s0025-5718-2010-02438-x","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T14:39:57Z","timestamp":1293633597000},"page":"1369-1396","source":"Crossref","is-referenced-by-count":162,"title":["Finite difference\/spectral approximations for the fractional cable equation"],"prefix":"10.1090","volume":"80","author":[{"given":"Yumin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanju","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"14","published-online":{"date-parts":[[2010,12,2]]},"reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"F. Amblard, A. C. Maggs, B. Yurke, A. N. Pargellis, and S. Leibler. Subdiffusion and anomalous local viscoelasticity in actin networks. Phys. Rev. Lett., 77:4470, 1996.","DOI":"10.1103\/PhysRevLett.77.4470"},{"issue":"1","key":"2","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1103\/PhysRevE.61.132","article-title":"From continuous time random walks to the fractional Fokker-Planck equation","volume":"61","author":"Barkai, E.","year":"2000","journal-title":"Phys. Rev. E (3)","ISSN":"https:\/\/id.crossref.org\/issn\/1539-3755","issn-type":"print"},{"key":"3","series-title":"Math\\'{e}matiques \\& Applications (Berlin) [Mathematics \\& Applications]","isbn-type":"print","volume-title":"Approximations spectrales de probl\\`emes aux limites elliptiques","volume":"10","author":"Bernardi, Christine","year":"1992","ISBN":"https:\/\/id.crossref.org\/isbn\/2287003878"},{"key":"4","isbn-type":"print","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S1570-8659(97)80003-8","article-title":"Spectral methods","author":"Bernardi, Christine","year":"1997","ISBN":"https:\/\/id.crossref.org\/isbn\/044482278X"},{"issue":"4-5","key":"5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0370-1573(90)90099-N","article-title":"Anomalous diffusion in disordered media: statistical mechanisms, models and physical applications","volume":"195","author":"Bouchaud, Jean-Philippe","year":"1990","journal-title":"Phys. Rep.","ISSN":"https:\/\/id.crossref.org\/issn\/0370-1573","issn-type":"print"},{"key":"6","doi-asserted-by":"crossref","unstructured":"E. Brown, E. Wu, W. Zipfel, and W. Webb. Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery. Biophys. J., 77:2837\u20132849, 1999.","DOI":"10.1016\/S0006-3495(99)77115-8"},{"issue":"1","key":"7","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1137\/080714130","article-title":"Finite element method for the space and time fractional Fokker-Planck equation","volume":"47","author":"Deng, Weihua","year":"2008","journal-title":"SIAM J. Numer. Anal.","ISSN":"https:\/\/id.crossref.org\/issn\/0036-1429","issn-type":"print"},{"key":"8","doi-asserted-by":"crossref","unstructured":"M. Dentz, A. Cortis, H. Scher, and B. Berkowitz. Time behaviour of solute in heterogeneous media: Transition from anomalous to normal transport. Adv. Water Resources, 27:155\u2013173, 2004.","DOI":"10.1016\/j.advwatres.2003.11.002"},{"issue":"3","key":"9","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/num.20112","article-title":"Variational formulation for the stationary fractional advection dispersion equation","volume":"22","author":"Ervin, Vincent J.","year":"2006","journal-title":"Numer. Methods Partial Differential Equations","ISSN":"https:\/\/id.crossref.org\/issn\/0749-159X","issn-type":"print"},{"key":"10","doi-asserted-by":"crossref","unstructured":"T. Feder, I. Brust-Mascher, J. Slattery, B. Baird, and W. Webb. Constrained diffusion or immobile fraction on cell surfaces: A new interpretation. Biophys. J., 70:2767\u20132773, 1996.","DOI":"10.1016\/S0006-3495(96)79846-6"},{"key":"11","unstructured":"R. Ghosh. Mobility and clustering of individual low density lipoprotein receptor molecures on the surface of human skin fibroblasts. Ph.D. thesis. Cornell University, Ithaca, NY."},{"key":"12","doi-asserted-by":"crossref","unstructured":"R. Ghosh and W. Webb. Automated detection and tracking of individual and clustered cell surface low density lipoprotein receptor molecures. Biophys. J., 66:1301\u20131318, 1994.","DOI":"10.1016\/S0006-3495(94)80939-7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"I. Goychuk, E. Heinsalu, M. Patriarca, G. Schmid, and P\u00e4nggi. Current and universal scaling in anomalous transport. Phys. Rev. E, 73:020101, 2006.","DOI":"10.1103\/PhysRevE.73.020101"},{"key":"14","doi-asserted-by":"crossref","unstructured":"B. I. Henry, T. A. M. Langlands, and S. L. Wearne. Fractional cable models for spiny neuronal dendrites. Phys. Rev. Lett., 100(12):128103, 2008.","DOI":"10.1103\/PhysRevLett.100.128103"},{"key":"15","doi-asserted-by":"crossref","unstructured":"A. Hodgkin and A. Huxley. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol., 117:500\u2013544, 1952.","DOI":"10.1113\/jphysiol.1952.sp004764"},{"key":"16","unstructured":"J. Jack, D. Noble, and R. Tsien. Electrical current flow in excitable cells. Oxford University Press, Oxford, 1975."},{"key":"17","unstructured":"D. Junge. Nerve and Muscle Excitation (2nd edition ed.). Sinauer Associates, Inc., Sunderland, Massachusetts, 1981."},{"key":"18","doi-asserted-by":"crossref","unstructured":"C. Koch. Biophysics of Computation, Information Processing in Single neurons, Computational Neuroscience. Oxford University Press, New York, 1999.","DOI":"10.1093\/oso\/9780195104912.001.0001"},{"key":"19","doi-asserted-by":"crossref","unstructured":"A. Kusumi, C. Nakada, K. Ritchie, K. Murase, K. Suzuki, H. Murakoshi, R. Kasai, J. Kondo, and T. Fujiwara. Paradigm shift of the plasma membrane concept from two-dimensional continuum fluid to the partitioned fluid: Highspeed single-molecure tracking of membrane molecures. Annu. Rev. Biophys. Biomol. Struct., 34:351\u2013378, 2005.","DOI":"10.1146\/annurev.biophys.34.040204.144637"},{"issue":"2","key":"20","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jcp.2004.11.025","article-title":"The accuracy and stability of an implicit solution method for the fractional diffusion equation","volume":"205","author":"Langlands, T. A. M.","year":"2005","journal-title":"J. Comput. Phys.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9991","issn-type":"print"},{"issue":"5","key":"21","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1063\/1.1566452","article-title":"Anomalous diffusion: fractional Fokker-Planck equation and its solutions","volume":"44","author":"Lenzi, E. K.","year":"2003","journal-title":"J. Math. Phys.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2488","issn-type":"print"},{"issue":"3","key":"22","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1137\/080718942","article-title":"A space-time spectral method for the time fractional diffusion equation","volume":"47","author":"Li, Xianjuan","year":"2009","journal-title":"SIAM J. Numer. Anal.","ISSN":"https:\/\/id.crossref.org\/issn\/0036-1429","issn-type":"print"},{"issue":"2","key":"23","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.jcp.2007.02.001","article-title":"Finite difference\/spectral approximations for the time-fractional diffusion equation","volume":"225","author":"Lin, Yumin","year":"2007","journal-title":"J. Comput. Phys.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9991","issn-type":"print"},{"key":"24","unstructured":"F. Mainardi. Fractional diffusive waves in viscoelastic solids. Nonlinear Waves in Solids, pages 93\u201397, 1995."},{"issue":"1","key":"25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0370-1573(00)00070-3","article-title":"The random walk\u2019s guide to anomalous diffusion: a fractional dynamics approach","volume":"339","author":"Metzler, Ralf","year":"2000","journal-title":"Phys. Rep.","ISSN":"https:\/\/id.crossref.org\/issn\/0370-1573","issn-type":"print"},{"key":"26","doi-asserted-by":"crossref","unstructured":"R. Metzler, J. Klafter, and I. Sokolov. Anomalous transport in external fields: Continuous time random walks and fractional diffusion equations extended. Phys. Rev. E, 58:1621\u20131633, 1998.","DOI":"10.1103\/PhysRevE.58.1621"},{"key":"27","doi-asserted-by":"crossref","unstructured":"H. P. M\u00fcller, R. Kimmich, and J. Weis. NMR flow velocity mapping in random percolation model objects: Evidence for a power-law dependence of the volume-averaged velocity on the probe-volume radius. Phys. Rev. E, 54:5278\u20135285, 1996.","DOI":"10.1103\/PhysRevE.54.5278"},{"key":"28","series-title":"Mathematics in Science and Engineering","isbn-type":"print","volume-title":"Fractional differential equations","volume":"198","author":"Podlubny, Igor","year":"1999","ISBN":"https:\/\/id.crossref.org\/isbn\/0125588402"},{"key":"29","doi-asserted-by":"crossref","unstructured":"N. Qian and T. Sejnowski. An electro-diffusion model for computing membrane potentials and ionic concentrations in branching dendrites, spines and axons. Biol. Cybern., 62:1\u201315, 1989.","DOI":"10.1007\/BF00217656"},{"key":"30","doi-asserted-by":"crossref","unstructured":"W. Rall. Branching dendritic trees and motoneuron membrane resistivity. volume 1, pages 491\u2013527. 1959.","DOI":"10.1016\/0014-4886(59)90046-9"},{"key":"31","doi-asserted-by":"crossref","unstructured":"W. Rall. Core conductor theory and cable properties of neurons. In R. Poeter, editor, Handbook of Physiology: The Nervous System, Vol. 1 (Chapter 3), pages 39\u201397. American Physiological Society, Bethesda, MD, 1977.","DOI":"10.1002\/cphy.cp010103"},{"key":"32","doi-asserted-by":"crossref","unstructured":"K. Ritchie. Detection of non-Browian diffusion in the cell membrane in single molecure tracking. Biophys. J., 88:2266\u20132277, 2005.","DOI":"10.1529\/biophysj.104.054106"},{"issue":"10","key":"33","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1103\/PhysRevB.7.4491","article-title":"Stochastic transport in a disordered solid. I. Theory","volume":"7","author":"Scher, H.","year":"1973","journal-title":"Phys. Rev. B (3)","ISSN":"https:\/\/id.crossref.org\/issn\/0163-1829","issn-type":"print"},{"key":"34","doi-asserted-by":"crossref","unstructured":"H. Scher and E. Montroll. Anomalous transit-time dispersion in amorphous solids. Phys. Rev. B, 12:2455\u20132477, 1975.","DOI":"10.1103\/PhysRevB.12.2455"},{"key":"35","unstructured":"I. Segev, J. Fleshman, and R. Burke. Compartmental models of complex neurons. In C. Koch and I. Segev, editors, Methods in Neuronal Modelling. MIT Press, Cambridge, MA."},{"key":"36","doi-asserted-by":"crossref","unstructured":"R. Simson, B. Yang, S. Moore, P. Doherty, F. Walsh, and K. Jacobson. Structural mosaicism on the submicron scale in the plasma membrane. Biophys. J., 74:297\u2013308, 1998.","DOI":"10.1016\/S0006-3495(98)77787-2"},{"key":"37","doi-asserted-by":"crossref","unstructured":"P. Smith, I. Morrison, K. Wilson, N. Fernandez, and R. Cherry. Constrained diffusion or immobile fraction on cell surfaces: A new interpretation. Biophys. J., 76:3331\u20133344, 1999.","DOI":"10.1016\/S0006-3495(99)77486-2"},{"key":"38","doi-asserted-by":"crossref","unstructured":"M. Wachsmuth, T. Weidemann, G. M\\vv{u}ller, U. Hoffmann-Rohrer, T.Knoch, W. Waldeck, and J. Langowski. Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching. Biophys. J., 84:3353\u20133363, 2003.","DOI":"10.1016\/S0006-3495(03)70059-9"},{"key":"39","unstructured":"E. R. Weeks. Experimental studies of anomalous diffusion, blocking phenomena, and two-dimensional turbulence. Ph.D. thesis. University of Texas at Austin."},{"issue":"11","key":"40","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1063\/1.527251","article-title":"The fractional diffusion equation","volume":"27","author":"Wyss, Walter","year":"1986","journal-title":"J. Math. Phys.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2488","issn-type":"print"}],"container-title":["Mathematics of Computation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ams.org\/mcom\/2011-80-275\/S0025-5718-2010-02438-X\/S0025-5718-2010-02438-X.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ams.org\/mcom\/2011-80-275\/S0025-5718-2010-02438-X\/S0025-5718-2010-02438-X.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:51:53Z","timestamp":1776790313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ams.org\/mcom\/2011-80-275\/S0025-5718-2010-02438-X\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,2]]},"references-count":40,"journal-issue":{"issue":"275","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0025-5718-2010-02438-X"],"URL":"https:\/\/doi.org\/10.1090\/s0025-5718-2010-02438-x","archive":["CLOCKSS","Portico"],"relation":{},"ISSN":["1088-6842","0025-5718"],"issn-type":[{"value":"1088-6842","type":"electronic"},{"value":"0025-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12,2]]}}}