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However, the isolation of three different microtubule-severing proteins, p56, EF1\u03b1, and katanin, has only confused the issue because none of these proteins is directly activated by cyclin B\/cdc2. Here we use immunodepletion with antibodies specific for a vertebrate katanin homologue to demonstrate that katanin is responsible for the majority of M-phase severing activity inXenopus eggs. This result suggests that katanin is responsible for changes in microtubules occurring at mitosis. Immunofluorescence analysis demonstrated that katanin is concentrated at a microtubule-dependent structure at mitotic spindle poles inXenopus A6 cells and in human fibroblasts, suggesting a specific role in microtubule disassembly at spindle poles. Surprisingly, katanin was also found in adult mouse brain, indicating that katanin may have other functions distinct from its mitotic role.<\/jats:p>","DOI":"10.1091\/mbc.9.7.1847","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T23:13:15Z","timestamp":1372806795000},"page":"1847-1861","source":"Crossref","is-referenced-by-count":104,"title":["Katanin Is Responsible for the M-Phase Microtubule-severing Activity in<i>Xenopus<\/i>Eggs"],"prefix":"10.1091","volume":"9","author":[{"given":"Francis J.","family":"McNally","sequence":"first","affiliation":[{"name":"Section of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Section of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/39382","volume":"389","author":"Andersen S.S.L.","year":"1997","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02740651","volume":"12","author":"Baas P.W.","year":"1996","journal-title":"Mol. 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