{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:43:23Z","timestamp":1791481403208,"version":"4.3.4"},"reference-count":42,"publisher":"American Society for Cell Biology (ASCB)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>The CDC37 gene is essential for the activity of p60<jats:sup>v-src<\/jats:sup>when expressed in yeast cells. Since the activation pathway for p60<jats:sup>v-src<\/jats:sup>and steroid hormone receptors is similar, the present study analyzed the hormone-dependent transactivation by androgen receptors and glucocorticoid receptors in yeast cells expressing a mutant version of the CDC37gene. In this mutant, hormone-dependent transactivation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Cdc37p appears to function via the androgen receptor ligand-binding domain, although it does not influence receptor hormone-binding affinity. Models for Cdc37p regulation of steroid hormone receptors are discussed.<\/jats:p>","DOI":"10.1091\/mbc.8.12.2501","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T23:12:27Z","timestamp":1372806747000},"page":"2501-2509","source":"Crossref","is-referenced-by-count":45,"title":["Differential In Vivo Regulation of Steroid Hormone Receptor Activation by Cdc37p"],"prefix":"10.1091","volume":"8","author":[{"given":"Albert E.","family":"Fliss","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Anatomy, Mount Sinai Medical Center, New York, New York 10029; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Mount Sinai Medical Center, New York, New York 10029; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Boschelli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Wayne State Medical School, Detroit, Michigan 48201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avrom J.","family":"Caplan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Mount Sinai Medical Center, New York, New York 10029; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.7761850","volume":"268","author":"Bohen S.P.","year":"1995","journal-title":"Science"},{"key":"B3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1242\/jcs.105.2.519","volume":"105","author":"Boschelli F.","year":"1993","journal-title":"J. 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