{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:34:46Z","timestamp":1790681686490,"version":"4.1.0"},"reference-count":52,"publisher":"American Society for Cell Biology (ASCB)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>Calcineurin is a Ca<jats:sup>2+<\/jats:sup>-calmodulin\u2013dependent serine\/threonine protein phosphatase that has been implicated in various signaling pathways. Here we report the identification and characterization of calcineurin genes in Caenorhabditis elegans (cna-1 and cnb-1), which share high homology with Drosophila and mammalian calcineurin genes. C. elegans calcineurin binds calcium and functions as a heterodimeric protein phosphatase establishing its biochemical conservation in the nematode. Calcineurin is expressed in hypodermal seam cells, body-wall muscle, vulva muscle, neuronal cells, and in sperm and the spermatheca. cnb-1 mutants showed pleiotropic defects including lethargic movement and delayed egg-laying. Interestingly, these characteristic defects resembled phenotypes observed in gain-of-function mutants ofunc-43\/Ca<jats:sup>2+<\/jats:sup>-calmodulin\u2013dependent protein kinase II (CaMKII) and goa-1\/G<jats:sub>o<\/jats:sub>-protein \u03b1-subunit. Double mutants of cnb-1 andunc-43(gf) displayed an apparent synergistic severity of movement and egg-laying defects, suggesting that calcineurin may have an antagonistic role in CaMKII-regulated phosphorylation signaling pathways in C. elegans.<\/jats:p>","DOI":"10.1091\/mbc.e02-01-0005","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T02:16:29Z","timestamp":1031710589000},"page":"3281-3293","source":"Crossref","is-referenced-by-count":108,"title":["Calcineurin, a Calcium\/Calmodulin-dependent Protein Phosphatase, Is Involved in Movement, Fertility, Egg Laying, and Growth in<i>Caenorhabditis elegans<\/i>"],"prefix":"10.1091","volume":"13","author":[{"given":"Jaya","family":"Bandyopadhyay","sequence":"first","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungsoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Ran","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Parasitology, College of Medicine, Kon-Kuk University, Chungju 380-710, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhoon","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunki","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myon Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science, Yonsei University, Seoul 120-749, Korea; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Zannoni","sequence":"additional","affiliation":[{"name":"Waksman Institute, Rutgers University, Piscataway, New Jersey 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Singson","sequence":"additional","affiliation":[{"name":"Waksman Institute, Rutgers University, Piscataway, New Jersey 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Sook","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science, Yonsei University, Seoul 120-749, Korea; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohong","family":"Ahnn","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0014-5793(82)80759-X","volume":"150","author":"Aitken A.","year":"1982","journal-title":"FEBS Lett."},{"key":"B2","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1242\/jcs.111.24.3645","volume":"111","author":"Arduengo P.M.","year":"1998","journal-title":"J. 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