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We found a genetic interaction between hay andcdk7, and we propose that some of these phenotypes are due to transcriptional deficiencies. We also found more apoptotic cells in imaginal discs and in the CNS of hay mutant flies than in wild-type flies. Because this abnormal level of apoptosis was not detected in cdk7 flies, this phenotype could be related to defects in DNA repair. In addition the apoptosis induced by p53 Drosophila homolog (Dmp53) is suppressed in heterozygous hay flies.<\/jats:p>","DOI":"10.1091\/mbc.e02-02-0087","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T22:16:29Z","timestamp":1031696189000},"page":"3246-3256","source":"Crossref","is-referenced-by-count":28,"title":["DNA Repair and Transcriptional Effects of Mutations in TFIIH in\n                    <i>Drosophila<\/i>\n                    Development"],"prefix":"10.1091","volume":"13","author":[{"given":"Carlos","family":"Merino","sequence":"first","affiliation":[{"name":"Department of Genetics and Molecular Physiology, Institute of Biotechnology, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Morelos 62250, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Reynaud","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Physiology, Institute of Biotechnology, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Morelos 62250, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Physiology, Institute of Biotechnology, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Morelos 62250, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Zurita","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Physiology, Institute of Biotechnology, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Morelos 62250, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1242\/dev.117.1.29","volume":"117","author":"Abrams J.M.","year":"1993","journal-title":"Development"},{"key":"B2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0092-8674(00)80627-3","volume":"101","author":"Brodsky M.H.","year":"2000","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1126\/science.8465198","volume":"260","author":"Buratowski S.","year":"1993","journal-title":"Science"},{"key":"B4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0003-2697(81)90281-5","volume":"112","author":"Burnette W.","year":"1981","journal-title":"Anal. 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