{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:48:58Z","timestamp":1790743738728,"version":"4.1.0"},"reference-count":63,"publisher":"American Society for Cell Biology (ASCB)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>Neutrophil (PMN) transepithelial migration is dependent on the leukocyte \u03b2<jats:sub>2<\/jats:sub>integrin CD11b\/CD18, yet the identity of epithelial counterreceptors remain elusive. Recently, a JAM protein family member termed JAM-C was implicated in leukocyte adhesive interactions; however, its expression in epithelia and role in PMN-epithelial interactions are unknown. Here, we demonstrate that JAM-C is abundantly expressed basolaterally in intestinal epithelia and localizes to desmosomes but not tight junctions. Desmosomal localization of JAM-C was further confirmed by experiments aimed at selective disruption of tight junctions and desmosomes. In assays of PMN transepithelial migration, both JAM-C mAbs and JAM-C\/Fc chimeras significantly inhibited the rate of PMN transmigration. Additional experiments revealed specific binding of JAM-C to CD11b\/CD18 and provided evidence of other epithelial ligands for CD11b\/CD18. These findings represent the first demonstration of direct adhesive interactions between PMN and epithelial intercellular junctions (desmosomes) that regulate PMN transepithelial migration and also suggest that JAM-C may play a role in desmosomal structure\/function.<\/jats:p>","DOI":"10.1091\/mbc.e04-04-0317","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T18:22:39Z","timestamp":1087323759000},"page":"3926-3937","source":"Crossref","is-referenced-by-count":108,"title":["JAM-C Is a Component of Desmosomes and a Ligand for CD11b\/CD18-mediated Neutrophil Transepithelial Migration"],"prefix":"10.1091","volume":"15","author":[{"given":"Ke","family":"Zen","sequence":"first","affiliation":[{"name":"Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Babbin","sequence":"additional","affiliation":[{"name":"Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Whelan","sequence":"additional","affiliation":[{"name":"Raven biotechnologies, inc., South San Francisco, California 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Nusrat","sequence":"additional","affiliation":[{"name":"Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Parkos","sequence":"additional","affiliation":[{"name":"Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"REF1","doi-asserted-by":"crossref","unstructured":"Aggeler, J., and Seely, K. 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Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration.Blood100, 2479-2486.","DOI":"10.1182\/blood-2001-11-0098"},{"key":"REF30","doi-asserted-by":"crossref","unstructured":"Koeser, J., Troyanovsky, S.M., Grund, C., and Franke, W.W. (2003). De novo formation of desmosomes in cultured cells upon transfection of genes encoding specific desmosomal components.Exp. Cell Res.285, 114-130.","DOI":"10.1016\/S0014-4827(03)00016-8"},{"key":"REF31","doi-asserted-by":"crossref","unstructured":"Kotovuori, P.et al.(1993). The vascular E-selectin binds to the leukocyte integrins CD11\/CD18.Glycobiology3, 131-136.","DOI":"10.1093\/glycob\/3.2.131"},{"key":"REF32","doi-asserted-by":"crossref","unstructured":"Larson, R.S., and Springer, T.A. (1990). Structure and function of leukocyte integrins.Immunol. Rev.114, 181-217.","DOI":"10.1111\/j.1600-065X.1990.tb00565.x"},{"key":"REF33","doi-asserted-by":"crossref","unstructured":"Liang, T.W.et al.(2002). Vascular endothelial-junctional adhesion molecule (VE-JAM)\/JAM 2 interacts with T, NK, and dendritic cells through JAM 3.J. Immunol.168, 1618-1626.","DOI":"10.4049\/jimmunol.168.4.1618"},{"key":"REF34","doi-asserted-by":"crossref","unstructured":"Liang, T.W.et al.(2000). Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation.Am. J. Physiol. Cell. Physiol.279, C1733-C1743.","DOI":"10.1152\/ajpcell.2000.279.6.C1733"},{"key":"REF35","doi-asserted-by":"crossref","unstructured":"Liu, Y., Buhring, H.J., Zen, K., Burst, S.L., Schnell, F.J., Williams, I.R., and Parkos, C.A. (2002). Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration.J. Biol. Chem.277, 10028-10036.","DOI":"10.1074\/jbc.M109720200"},{"key":"REF36","doi-asserted-by":"crossref","unstructured":"Liu, Y., Merlin, D., Burst, S.L., Pochet, M., Madara, J.L., and Parkos, C.A. (2001). The role of CD47 in neutrophil transmigration. 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