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Cells expressing Scar lacking this N-terminal region show abnormalities in F-actin distribution, cell morphology, movement, and cytokinesis. This is true even in the presence of wild-type Scar. The data suggest that the first 96 amino acids of Scar are necessary for participation in a large-molecular-weight protein complex, and that this Scar-containing complex is responsible for the proper localization and regulation of Scar. The presence of mis-regulated or unregulated Scar has significant deleterious effects on cells and may explain the need to keep Scar activity tightly controlled in vivo either by assembly in a complex or by rapid degradation.<\/jats:p>","DOI":"10.1091\/mbc.e06-06-0518","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T02:03:02Z","timestamp":1172109782000},"page":"1609-1620","source":"Crossref","is-referenced-by-count":15,"title":["The N-Terminus of<i>Dictyostelium<\/i>Scar Interacts with Abi and HSPC300 and Is Essential for Proper Regulation and Function"],"prefix":"10.1091","volume":"18","author":[{"given":"Diana","family":"Caracino","sequence":"first","affiliation":[{"name":"*Department of Cell Biology and"},{"name":"Graduate Program in Microbiology and Molecular Genetics, Emory University School of Medicine, Atlanta, GA 30322; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Jones","sequence":"additional","affiliation":[{"name":"*Department of Cell Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Compton","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, School of Agriculture, University of Georgia, Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles L.","family":"Saxe","sequence":"additional","affiliation":[{"name":"*Department of Cell Biology and"},{"name":"Graduate Program in Microbiology and Molecular Genetics, Emory University School of Medicine, Atlanta, GA 30322; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1182\/blood.V93.6.2003.406k13_2003_2012","volume":"93","author":"Baba Y.","year":"1999","journal-title":"Blood"},{"key":"B2","unstructured":"Bear J. 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