{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:13:07Z","timestamp":1791105187722,"version":"4.1.0"},"reference-count":47,"publisher":"American Society for Cell Biology (ASCB)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>During their migration to the periphery, cranial neural crest cells (NCCs) are repulsed by an ErbB4-dependent cue(s) in the mesenchyme adjoining rhombomeres (r) 3 and 5, which are segmented hindbrain neuromeres. ErbB4 has many ligands, but which ligand functions in the above system has not yet been clearly determined. Here we found that a cornichon-like protein\/cornichon homolog 2 (CNIL\/CNIH2) gene was expressed in the developing chick r3 and r5. In a cell culture system, its product facilitated the secretion of heparin-binding epidermal growth factor-like growth factor (HB-EGF), one of the ligands of ErbB4. When CNIL function was perturbed in chick embryos by forced expression of a truncated form of CNIL, the distribution of NCCs was affected, which resulted in abnormal nerve fiber connections among the cranial sensory ganglia. Also, knockdown of CNIL or HB-EGF with siRNAs yielded a similar phenotype. This phenotype closely resembled that of ErbB4 knockout mouse embryos. Because HB-EGF was uniformly expressed in the embryonic hindbrain, CNIL seems to confine the site of HB-EGF action to r3 and r5 in concert with ErbB4.<\/jats:p>","DOI":"10.1091\/mbc.e06-08-0733","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T01:53:36Z","timestamp":1169085216000},"page":"1143-1152","source":"Crossref","is-referenced-by-count":26,"title":["Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves"],"prefix":"10.1091","volume":"18","author":[{"given":"Hideharu","family":"Hoshino","sequence":"first","affiliation":[{"name":"*Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Uchida","sequence":"additional","affiliation":[{"name":"*Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Otsuki","sequence":"additional","affiliation":[{"name":"*Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Research Information Research Division, National Institute of Informatics, Tokyo 101-8430, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousaku","family":"Okubo","sequence":"additional","affiliation":[{"name":"Laboratory for Gene Expression Analysis, Center for Information Biology, National Institute of Genetics, Shizuoka 411-8540, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Takeichi","sequence":"additional","affiliation":[{"name":"Laboratory for Cell Adhesion and Tissue Patterning, Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Chisaka","sequence":"additional","affiliation":[{"name":"*Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1242\/dev.02219","volume":"133","author":"Boekel C.","year":"2006","journal-title":"Development"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1101\/gad.12.12.1825","volume":"12","author":"Britsch S.","year":"1998","journal-title":"Genes Dev"},{"key":"B3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-4827(02)00100-3","volume":"284","author":"Carpenter G.","year":"2003","journal-title":"Exp. 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