{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:50:31Z","timestamp":1790895031493,"version":"4.1.0"},"reference-count":55,"publisher":"American Society for Cell Biology (ASCB)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p>\u03b1-Dystroglycan (\u03b1-DG) is an important cellular receptor for extracellular matrix (ECM) proteins as well as the Old World arenaviruses lymphocytic choriomeningitis virus (LCMV) and the human pathogenic Lassa fever virus (LFV). Specific O-glycosylation of \u03b1-DG is critical for its function as receptor for ECM proteins and arenaviruses. Here, we investigated the impact of arenavirus infection on \u03b1-DG expression. Infection with an immunosuppressive LCMV isolate caused a marked reduction in expression of functional \u03b1-DG without affecting biosynthesis of DG core protein or global cell surface glycoprotein expression. The effect was caused by the viral glycoprotein (GP), and it critically depended on \u03b1-DG binding affinity and GP maturation. An equivalent effect was observed with LFVGP. Viral GP was found to associate with a complex between DG and the glycosyltransferase LARGE in the Golgi. Overexpression of LARGE restored functional \u03b1-DG expression in infected cells. We provide evidence that virus-induced down-modulation of functional \u03b1-DG perturbs DG-mediated assembly of laminin at the cell surface, affecting normal cell\u2013matrix interactions.<\/jats:p>","DOI":"10.1091\/mbc.e07-04-0374","type":"journal-article","created":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T01:28:41Z","timestamp":1188437321000},"page":"4493-4507","source":"Crossref","is-referenced-by-count":44,"title":["Old World Arenavirus Infection Interferes with the Expression of Functional \u03b1-Dystroglycan in the Host Cell"],"prefix":"10.1091","volume":"18","author":[{"given":"Jillian M.","family":"Rojek","sequence":"first","affiliation":[{"name":"*Viral Immunobiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Departments of Molecular Physiology and Biophysics, Neurology, and Internal Medicine, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.A.","family":"Oldstone","sequence":"additional","affiliation":[{"name":"*Viral Immunobiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kunz","sequence":"additional","affiliation":[{"name":"*Viral Immunobiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1128\/JVI.00208-06","volume":"80","author":"Agnihothram S. 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