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Wiskott Aldrich Syndrome Protein (WASp) Interacting Protein (WIP)\u2212\/\u2212 OCs were devoid of podosomes, but they still exhibited actin clouds. Indeed, WIP\u2212\/\u2212 OCs show diminished expression of WASp, which is required for podosome formation. CD44 is a novel marker of OC podosome cores and the first nonintegrin receptor detected in these structures. The importance of CD44 is revealed by showing that its clustering restores podosome cores and WASp expression in WIP\u2212\/\u2212 OCs. However, although CD44 signals are sufficient to form a SZ, the presence of WIP is indispensable for the formation of a fully functional SZ.<\/jats:p>","DOI":"10.1091\/mbc.e07-04-0378","type":"journal-article","created":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T00:48:07Z","timestamp":1190854087000},"page":"4899-4910","source":"Crossref","is-referenced-by-count":157,"title":["CD44 and \u03b23 Integrin Organize Two Functionally Distinct Actin-based Domains in Osteoclasts"],"prefix":"10.1091","volume":"18","author":[{"given":"Anne","family":"Chabadel","sequence":"first","affiliation":[{"name":"*Institut de G\u00e9nomique Fonctionnelle de Lyon, Universit\u00e9 de Lyon, Institut F\u00e9d\u00e9ratif Biosciences Gerland Lyon Sud, Universit\u00e9 Lyon 1, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Ba\u00f1on-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa,\u201d Consejo Superior de Investigaciones Cientificas-Universidad Autonoma de Madrid, 28049 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cluet","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, Unite Mixte de Recherche 5239 Centre National de la Recherche Scientifique\/Ecole Normale Sup\u00e9rieure Lyon, Universit\u00e9 Lyon I, Institut F\u00e9d\u00e9ratif de Recherche \u201cBioSciences Lyon-Gerland,\u201d Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian B.","family":"Rudkin","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, Unite Mixte de Recherche 5239 Centre National de la Recherche Scientifique\/Ecole Normale Sup\u00e9rieure Lyon, Universit\u00e9 Lyon I, Institut F\u00e9d\u00e9ratif de Recherche \u201cBioSciences Lyon-Gerland,\u201d Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Wehrle-Haller","sequence":"additional","affiliation":[{"name":"Department of Cellular Physiology and Metabolism, Centre M\u00e9dical Universitaire, 1211 Geneva 4, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Genot","sequence":"additional","affiliation":[{"name":"European Institute of Chemistry and Biology, Unit\u00e9 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 889, Universit\u00e9 Victor Segalen Bordeaux 2, L'Institut F\u00e9d\u00e9ratif de Recherche 66, 33 600 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Jurdic","sequence":"additional","affiliation":[{"name":"*Institut de G\u00e9nomique Fonctionnelle de Lyon, Universit\u00e9 de Lyon, Institut F\u00e9d\u00e9ratif Biosciences Gerland Lyon Sud, Universit\u00e9 Lyon 1, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines M.","family":"Anton","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa,\u201d Consejo Superior de Investigaciones Cientificas-Universidad Autonoma de Madrid, 28049 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Saltel","sequence":"additional","affiliation":[{"name":"*Institut de G\u00e9nomique Fonctionnelle de Lyon, Universit\u00e9 de Lyon, Institut F\u00e9d\u00e9ratif Biosciences Gerland Lyon Sud, Universit\u00e9 Lyon 1, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon, France;"},{"name":"European Institute of Chemistry and Biology, Unit\u00e9 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 889, Universit\u00e9 Victor Segalen Bordeaux 2, L'Institut F\u00e9d\u00e9ratif de Recherche 66, 33 600 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1074-7613(02)00268-6","volume":"16","author":"Anton I. 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