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Furthermore, adding synthetic A\u03b2 peptide, the pathogenic product of APP, to cultured cells causes rapid and robust chromosome mis-segregation leading to aneuploid, including trisomy 21, daughters, which is prevented by LiCl addition or Ca<jats:sup>2+<\/jats:sup> chelation and is replicated in tau KO cells, implicating GSK-3\u03b2, calpain, and Tau-dependent microtubule transport in the aneugenic activity of A\u03b2. Furthermore, APP KO cells are resistant to the aneugenic activity of A\u03b2, as they have been shown previously to be resistant to A\u03b2-induced tau phosphorylation and cell toxicity. These results indicate that A\u03b2-induced microtubule dysfunction leads to aneuploid neurons and may thereby contribute to the pathogenesis of AD. <\/jats:p>","DOI":"10.1091\/mbc.e09-10-0850","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T22:45:09Z","timestamp":1261608309000},"page":"511-520","source":"Crossref","is-referenced-by-count":71,"title":["Alzheimer A\u03b2 Peptide Induces Chromosome Mis-Segregation and Aneuploidy, Including Trisomy 21: Requirement for Tau and APP"],"prefix":"10.1091","volume":"21","author":[{"given":"Antoneta","family":"Granic","sequence":"first","affiliation":[{"name":"*Eric Pfeiffer Suncoast Alzheimer's Center,"},{"name":"Florida Alzheimer's Disease Research Center,"},{"name":"Department of Molecular Medicine, College of Medicine, and"},{"name":"School of Aging Studies, College of Behavioral and Community Sciences, University of South Florida, Tampa FL, 33613"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"*Eric Pfeiffer Suncoast Alzheimer's Center,"},{"name":"Byrd Alzheimer's Institute,"},{"name":"Department of Molecular Medicine, College of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Norden","sequence":"additional","affiliation":[{"name":"*Eric Pfeiffer Suncoast Alzheimer's Center,"},{"name":"Byrd Alzheimer's Institute,"},{"name":"Florida Alzheimer's Disease Research Center,"},{"name":"Department of Molecular Medicine, College of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huntington","family":"Potter","sequence":"additional","affiliation":[{"name":"*Eric Pfeiffer Suncoast Alzheimer's Center,"},{"name":"Byrd Alzheimer's Institute,"},{"name":"Florida Alzheimer's Disease Research Center,"},{"name":"Department of Molecular Medicine, College of Medicine, and"},{"name":"School of Aging Studies, College of Behavioral and Community Sciences, University of South Florida, Tampa FL, 33613"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1016\/j.neurobiolaging.2006.10.027","volume":"29","author":"Boeras D. 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