{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:39:36Z","timestamp":1788435576015,"version":"build-2803163510"},"reference-count":98,"publisher":"American Society for Cell Biology (ASCB)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2010,7,15]]},"abstract":"<jats:p>Nuclear receptor coactivator 6 (NCOA6) is a multifunctional protein implicated in embryonic development, cell survival, and homeostasis. An 81-amino acid fragment, dnNCOA6, containing the N-terminal nuclear receptor box (LXXLL motif) of NCOA6, acts as a dominant-negative (dn) inhibitor of NCOA6. Here, we expressed dnNCOA6 in postmitotic transgenic mouse lens fiber cells. The transgenic lenses showed reduced growth; a wide spectrum of lens fiber cell differentiation defects, including reduced expression of \u03b3-crystallins; and cataract formation. Those lens fiber cells entered an alternate proapoptotic pathway, and the denucleation (karyolysis) process was stalled. Activation of caspase-3 at embryonic day (E)13.5 was followed by double-strand breaks (DSBs) formation monitored via a biomarker, \u03b3-H2AX. Intense terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) signals were found at E16.5. Thus, a window of \u223c72 h between these events suggested prolonged though incomplete apoptosis in the lens fiber cell compartment that preserved nuclei in its cells. Genetic experiments showed that the apoptotic-like processes in the transgenic lens were both p53-dependent and p53-independent. Lens-specific deletion of Ncoa6 also resulted in disrupted lens fiber cell differentiation. Our data demonstrate a cell-autonomous role of Ncoa6 in lens fiber cell differentiation and suggest novel insights into the process of lens fiber cell denucleation and apoptosis.<\/jats:p>","DOI":"10.1091\/mbc.e09-12-1031","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T02:37:01Z","timestamp":1274323021000},"page":"2453-2468","source":"Crossref","is-referenced-by-count":37,"title":["Lens Fiber Cell Differentiation and Denucleation Are Disrupted through Expression of the N-Terminal Nuclear Receptor Box of<i>Ncoa6<\/i>and Result in p53-dependent and p53-independent Apoptosis"],"prefix":"10.1091","volume":"21","author":[{"given":"Wei-Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Departments of *Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Cvekl","sequence":"additional","affiliation":[{"name":"Departments of *Genetics and"},{"name":"Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","first-page":"3575","volume":"43","author":"Alge C. S.","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"B2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.preteyeres.2006.10.003","volume":"26","author":"Andley U. P.","year":"2007","journal-title":"Prog. Retin. Eye Res"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1128\/MCB.23.4.1260-1268.2003","volume":"23","author":"Antonson P.","year":"2003","journal-title":"Mol. Cell Biol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.277.5328.965","volume":"277","author":"Anzick S. L.","year":"1997","journal-title":"Science"},{"key":"B5","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1101\/gad.184000","volume":"14","author":"Ashery-Padan R.","year":"2000","journal-title":"Genes Dev"},{"key":"B6","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1073\/pnas.89.8.3347","volume":"89","author":"Balkan W.","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exer.2001.1111","volume":"74","author":"Bassnett S.","year":"2002","journal-title":"Exp. Eye Res"},{"key":"B8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.exer.2008.08.017","volume":"88","author":"Bassnett S.","year":"2009","journal-title":"Exp. Eye Res"},{"key":"B9","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.cell.2006.09.045","volume":"127","author":"Cang Y.","year":"2006","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"crossref","first-page":"R488","DOI":"10.1016\/S0960-9822(03)00410-X","volume":"13","author":"Canman C. E.","year":"2003","journal-title":"Curr. Biol"},{"key":"B11","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1101\/gad.1015202","volume":"16","author":"Chan D. W.","year":"2002","journal-title":"Genes Dev"},{"key":"B12","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/nar\/gkh334","volume":"32","author":"Chauhan B. K.","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"B13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.onc.1205050","volume":"21","author":"Chen Q.","year":"2002","journal-title":"Oncogene"},{"key":"B14","first-page":"4223","volume":"41","author":"Chen Q.","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"B15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000082285","volume":"26","author":"Chen Q.","year":"2004","journal-title":"Dev. Neurocci"},{"key":"B16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.preteyeres.2007.07.002","volume":"26","author":"Cvekl A.","year":"2007","journal-title":"Prog. Retin. Eye Res"},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.1038\/hdy.2010.16","volume":"105","author":"Cvekl A.","year":"2010","journal-title":"Heredity"},{"key":"B18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1006\/exer.2001.1001","volume":"72","author":"de Iongh R. U.","year":"2001","journal-title":"Exp. Eye Res"},{"key":"B19","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/j.1460-2075.1992.tb05294.x","volume":"11","author":"Denecke J.","year":"1992","journal-title":"EMBO J"},{"key":"B20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/356215a0","volume":"356","author":"Donehower L. A.","year":"1992","journal-title":"Nature"},{"key":"B21","first-page":"464","volume":"41","author":"Duncan M. K.","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"B22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/dbio.2000.9652","volume":"221","author":"Enwright J. F.","year":"2000","journal-title":"Dev. Biol"},{"key":"B23","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s10495-009-0346-6","volume":"14","author":"Feinstein-Rotkopf Y.","year":"2009","journal-title":"Apoptosis"},{"key":"B24","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.dnarep.2004.03.024","volume":"3","author":"Fernandez-Capetillo O.","year":"2004","journal-title":"DNA Rep"},{"key":"B25","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1128\/MCB.14.10.6743","volume":"14","author":"Fromm L.","year":"1994","journal-title":"Mol. Cell Biol"},{"key":"B26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/MCB.19.1.353","volume":"19","author":"Gomez Lahoz E.","year":"1999","journal-title":"Mol. Cell Biol"},{"key":"B27","doi-asserted-by":"crossref","first-page":"17954","DOI":"10.1074\/jbc.273.28.17954","volume":"273","author":"Gopal-Srivastava R.","year":"1998","journal-title":"J. Biol. Chem"},{"key":"B28","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nrg1202","volume":"4","author":"Graw J.","year":"2003","journal-title":"Nat. Rev. Genet"},{"key":"B29","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1387\/ijdb.041854jg","volume":"48","author":"Graw J.","year":"2004","journal-title":"Int. J. Dev. Biol"},{"key":"B30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2008.10.011","volume":"88","author":"Graw J.","year":"2009","journal-title":"Exp. Eye Res"},{"key":"B31","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1167\/iovs.03-0811","volume":"45","author":"Graw J.","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"B32","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.semcdb.2006.10.004","volume":"17","author":"Griep A. E.","year":"2006","journal-title":"Semin. Cell Dev. Biol"},{"key":"B33","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1128\/JVI.67.3.1373-1384.1993","volume":"67","author":"Griep A. E.","year":"1993","journal-title":"J. Virol"},{"key":"B34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/dbio.2000.9699","volume":"222","author":"Hettmann T.","year":"2000","journal-title":"Dev. Biol"},{"key":"B35","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","volume":"273","author":"Janicke R. U.","year":"1998","journal-title":"J. Biol. Chem"},{"key":"B36","doi-asserted-by":"crossref","first-page":"38731","DOI":"10.1074\/jbc.M201770200","volume":"277","author":"Kamradt M. C.","year":"2002","journal-title":"J. Biol. Chem"},{"key":"B37","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1182\/blood.V94.10.3523.422k07_3523_3530","volume":"94","author":"Kawabata Y.","year":"1999","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"crossref","first-page":"19254","DOI":"10.1074\/jbc.274.27.19254","volume":"274","author":"Kawauchi S.","year":"1999","journal-title":"J. Biol. Chem"},{"key":"B39","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1073\/pnas.96.7.3781","volume":"96","author":"Kim J. I.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B40","doi-asserted-by":"crossref","first-page":"8409","DOI":"10.1128\/MCB.22.24.8409-8414.2002","volume":"22","author":"Kim S. W.","year":"2002","journal-title":"Mol. Cell Biol"},{"key":"B41","doi-asserted-by":"crossref","first-page":"45356","DOI":"10.1074\/jbc.C200509200","volume":"277","author":"Kuang S. Q.","year":"2002","journal-title":"J. Biol. Chem"},{"key":"B42","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ydbio.2005.06.010","volume":"284","author":"Lee H. Y.","year":"2005","journal-title":"Dev. Biol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-01-0010"},{"key":"B44","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10495-009-0324-z","volume":"14","author":"Lippens S.","year":"2009","journal-title":"Apoptosis"},{"key":"B45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1101\/gad.1180204","volume":"18","author":"Liu K.","year":"2004","journal-title":"Genes Dev"},{"key":"B46","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1038\/sj.emboj.7601398","volume":"25","author":"Liu W.","year":"2006","journal-title":"EMBO J"},{"key":"B47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.01.020","volume":"280","author":"Lovicu F. J.","year":"2005","journal-title":"Dev. Biol"},{"key":"B48","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1128\/MCB.24.11.4994-5004.2004","volume":"24","author":"Mahajan M. A.","year":"2004","journal-title":"Mol. Cell Biol"},{"key":"B49","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1210\/me.2005-0529","volume":"21","author":"Mahajan M. A.","year":"2007","journal-title":"Mol. Endocrinol"},{"key":"B50","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.06002","volume":"6","author":"Mahajan M. A.","year":"2008","journal-title":"Nucl. Recept. Signal"},{"key":"B51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/42475","volume":"387","author":"Mathers P. H.","year":"1997","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/371072a0","volume":"371","author":"Morgenbesser S. D.","year":"1994","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1242\/dev.02262","volume":"133","author":"Morozov V.","year":"2006","journal-title":"Development"},{"key":"B54","doi-asserted-by":"crossref","first-page":"6142","DOI":"10.1073\/pnas.92.13.6142","volume":"92","author":"Nakamura T.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B55","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature01895","volume":"424","author":"Nishimoto S.","year":"2003","journal-title":"Nature"},{"key":"B56","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1073\/pnas.82.23.7815","volume":"82","author":"Overbeek P. A.","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B57","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1101\/gad.8.11.1285","volume":"8","author":"Pan H.","year":"1994","journal-title":"Genes Dev"},{"key":"B58","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1101\/gad.9.17.2157","volume":"9","author":"Pan H.","year":"1995","journal-title":"Genes Dev"},{"key":"B59","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0962-8924(03)00170-3","volume":"13","author":"Petrini J. H.","year":"2003","journal-title":"Trends Cell Biol"},{"key":"B60","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1432-0436.1981.tb01141.x","volume":"19","author":"Piatigorsky J.","year":"1981","journal-title":"Differentiation"},{"key":"B61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-213X-7-39","volume":"7","author":"Pirity M. K.","year":"2007","journal-title":"BMC Dev. Biol"},{"key":"B62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"Porter A. G.","year":"1999","journal-title":"Cell Death Differ"},{"key":"B63","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1242\/dev.124.15.2935","volume":"124","author":"Porter F. D.","year":"1997","journal-title":"Development"},{"key":"B64","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/bjc.1996.624","volume":"74","author":"Potten C. S.","year":"1996","journal-title":"Br. J. Cancer"},{"key":"B65","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0022-5320(74)80059-6","volume":"46","author":"Rafferty N. S.","year":"1974","journal-title":"J. Ultrastruct. Res"},{"key":"B66","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1128\/MCB.24.13.5694-5709.2004","volume":"24","author":"Rajaram N.","year":"2004","journal-title":"Mol. Cell Biol"},{"key":"B67","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/dev.127.2.307","volume":"127","author":"Ring B. Z.","year":"2000","journal-title":"Development"},{"key":"B68","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.semcdb.2006.10.002","volume":"17","author":"Robinson M. L.","year":"2006","journal-title":"Semin. Cell Dev. Biol"},{"key":"B69","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1101\/gad.5.8.1333","volume":"5","author":"Rossant J.","year":"1991","journal-title":"Genes Dev"},{"key":"B70","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/nar\/29.5.1228","volume":"29","author":"Sakai M.","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"B71","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1093\/emboj\/cdf609","volume":"21","author":"Sandilands A.","year":"2002","journal-title":"EMBO J"},{"key":"B72","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1242\/dev.032888","volume":"136","author":"Shaham O.","year":"2009","journal-title":"Development"},{"key":"B73","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nri1809","volume":"6","author":"Siegel R. M.","year":"2006","journal-title":"Nat. Rev. Immunol"},{"key":"B74","volume-title":"Systematic Evaluation of the Mouse Eye: Anatomy, Pathology and Biomethods","author":"Smith R. S.","year":"2002"},{"key":"B75","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s10495-007-0131-3","volume":"12","author":"Stanton S. E.","year":"2007","journal-title":"Apoptosis"},{"key":"B76","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1073\/pnas.0712034105","volume":"105","author":"Stegh A. H.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B77","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/dbio.1999.9557","volume":"217","author":"Stolen C. M.","year":"2000","journal-title":"Dev. Biol"},{"key":"B78","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1128\/MCB.00846-06","volume":"27","author":"Swamynathan S. K.","year":"2007","journal-title":"Mol. Cell Biol"},{"key":"B79","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.molcel.2005.05.008","volume":"18","author":"Thiriet C.","year":"2005","journal-title":"Mol. Cell"},{"key":"B80","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1101\/gad.7.2.295","volume":"7","author":"Tini M.","year":"1993","journal-title":"Genes Dev"},{"key":"B81","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0014-4835(91)90017-9","volume":"52","author":"Vrensen G. F.","year":"1991","journal-title":"Exp. Eye Res"},{"key":"B82","doi-asserted-by":"crossref","first-page":"19986","DOI":"10.1074\/jbc.M501689200","volume":"280","author":"Wang Y.","year":"2005","journal-title":"J. Biol. Chem"},{"key":"B83","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0012-1606(90)90008-7","volume":"137","author":"Wawrousek E. F.","year":"1990","journal-title":"Dev. Biol"},{"key":"B84","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/SQB.1985.050.01.051","volume":"50","author":"Westphal H.","year":"1985","journal-title":"Cold Spring Harb. Symp. Quant. Biol"},{"key":"B85","doi-asserted-by":"crossref","first-page":"e4159","DOI":"10.1371\/journal.pone.0004159","volume":"4","author":"Wolf L. V.","year":"2009","journal-title":"PLoS One"},{"key":"B86","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.1074\/jbc.M708704200","volume":"283","author":"Xi J. H.","year":"2008","journal-title":"J. Biol. Chem"},{"key":"B87","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ydbio.2006.06.045","volume":"298","author":"Xie L.","year":"2006","journal-title":"Dev. Biol"},{"key":"B88","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1242\/dev.00399","volume":"130","author":"Yamada R.","year":"2003","journal-title":"Development"},{"key":"B89","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1432-0436.2006.00068.x","volume":"74","author":"Yan Q.","year":"2006","journal-title":"Differentiation"},{"key":"B90","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jmb.2004.07.102","volume":"344","author":"Yang Y.","year":"2004","journal-title":"J. Mol. Biol"},{"key":"B91","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1038\/sj.emboj.7601114","volume":"25","author":"Yang Y.","year":"2006","journal-title":"EMBO J"},{"key":"B92","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.dnarep.2006.05.004","volume":"5","author":"Yang Y. G.","year":"2006","journal-title":"DNA Rep"},{"key":"B93","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1128\/MCB.01412-05","volume":"26","author":"Yeom S. Y.","year":"2006","journal-title":"Mol. Cell Biol"},{"key":"B94","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nature03964","volume":"437","author":"Yoshida H.","year":"2005","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"crossref","first-page":"13618","DOI":"10.1073\/pnas.95.23.13618","volume":"95","author":"Zheng T. S.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B96","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nrm1443","volume":"5","author":"Zhivotovsky B.","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"B97","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1074\/jbc.C200634200","volume":"278","author":"Zhu Y. J.","year":"2003","journal-title":"J. Biol. Chem"},{"key":"B98","doi-asserted-by":"crossref","first-page":"14485","DOI":"10.1074\/jbc.M900935200","volume":"284","author":"Zhu Y. T.","year":"2009","journal-title":"J. Biol. Chem"}],"container-title":["Molecular Biology of the Cell"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T01:27:18Z","timestamp":1635384438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.molbiolcell.org\/doi\/10.1091\/mbc.e09-12-1031"}},"subtitle":[],"editor":[{"given":"M. Bishr","family":"Omary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,7,15]]},"references-count":98,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,7,15]]}},"alternative-id":["10.1091\/mbc.e09-12-1031"],"URL":"https:\/\/doi.org\/10.1091\/mbc.e09-12-1031","relation":{},"ISSN":["1059-1524","1939-4586"],"issn-type":[{"value":"1059-1524","type":"print"},{"value":"1939-4586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,15]]}}}