{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:25:30Z","timestamp":1790810730940,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Cell Biology (ASCB)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Angiogenesis\u2014the growth of new blood vessels from preexisting vessels\u2014is an important physiological process and is considered to play a key role in tumor growth and metastasis. We identified the immunoglobulin-containing and proline-rich receptor-1 (IGPR-1, also called TMIGD2) gene as a novel cell adhesion receptor that is expressed in various human organs and tissues, mainly in cells with epithelium and endothelium origins. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell\u2013cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)\u2013containing signaling proteins, including SH3 protein interacting with Nck (SPIN90\/WISH), bullous pemphigoid antigen-1, and calcium channel \u03b22. Silencing of expression of SPIN90\/WISH by siRNA in endothelial cells showed that SPIN90\/WISH is required for capillary tube formation. These features of IGPR-1 suggest that IGPR-1 is a novel receptor that plays an important role in cell\u2013cell interaction, cell migration, and angiogenesis.<\/jats:p>","DOI":"10.1091\/mbc.e11-11-0934","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T05:56:43Z","timestamp":1331791003000},"page":"1646-1656","source":"Crossref","is-referenced-by-count":59,"title":["Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis"],"prefix":"10.1091","volume":"23","author":[{"given":"Nader","family":"Rahimi","sequence":"first","affiliation":[{"name":"Departments of Pathology and Ophthalmology, School of Medicine, Boston University, Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kobra","family":"Rezazadeh","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Ophthalmology, School of Medicine, Boston University, Boston, MA 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