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In other epithelial cell types these activating mAbs inhibit growth factor\u2013induced down-regulation of adhesion and epithelial morphogenesis, indicating that these phenomena are also controlled by E-cadherin activity at the cell surface. Both types of mAbs recognize conformational epitopes at different interfaces between extracellular cadherin repeat domains (ECs), especially near calcium-binding sites. Activation also induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain. Moreover, phospho-site mutations indicate that dephosphorylation of specific Ser\/Thr residues in the N-terminal domain of p120-catenin mediate adhesion activation. Thus physiological regulation of the adhesive state of E-cadherin involves physical and\/or conformational changes in the EC interface regions of the ectodomain at the cell surface that are mediated by catenin-associated changes across the membrane.<\/jats:p>","DOI":"10.1091\/mbc.e11-12-1060","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:41:53Z","timestamp":1334796113000},"page":"2092-2108","source":"Crossref","is-referenced-by-count":74,"title":["Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion"],"prefix":"10.1091","volume":"23","author":[{"given":"Yuliya I.","family":"Petrova","sequence":"first","affiliation":[{"name":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MarthaJoy M.","family":"Spano","sequence":"additional","affiliation":[{"name":"Department of Cell 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