{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:38:25Z","timestamp":1787661505549,"version":"build-2736575974"},"reference-count":40,"publisher":"American Society for Cell Biology (ASCB)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p> In Neurospora crassa and other filamentous fungi, light-dependent\u2013specific phenomena are regulated by transcription factors WC-1 and WC-2. In addition to its transcriptional activity, WC-1 is able to directly sense light stimuli through a LOV sensor domain. Its location in the nucleus and heterodimerization with WC-2, together with the presence of a zinc-finger DNA-binding domain and an environmental sensor domain, all resemble the functional evolutionary architecture adopted by vertebrate nuclear receptors (NRs). Here we describe a scenario in which WC-1 represents a functional orthologue of NRs and acts through association with the chromatin-modifying coactivator NGF-1, which encodes a homologue of the yeast Gcn5p acetyltransferase. To support this view, we show a direct association between WC-1 and NGF-1 that depends on a WC-1 region containing a conserved functional LXXLL motif, a signature previously described as being an exclusive feature of NR\/coactivator interaction. Our data suggest that a WC-1\/NGF-1 complex is preassembled in the dark on light-inducible promoters and that, after exposure to light stimulation, NGF-1\u2013associated HAT activity leads to histone H3 acetylation and transcriptional activation. Finally, we provide evidence for a NGF-1\u2013independent acetylated form of WC-1. Overall our data indicate that Neurospora and higher eukaryotes share a common mechanism for the signal transduction of environmental stimuli. <\/jats:p>","DOI":"10.1091\/mbc.e12-02-0142","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T06:07:58Z","timestamp":1344492478000},"page":"3863-3872","source":"Crossref","is-referenced-by-count":44,"title":["Physical association of the WC-1 photoreceptor and the histone acetyltransferase NGF-1 is required for blue light signal transduction in <i>Neurospora crassa<\/i>"],"prefix":"10.1091","volume":"23","author":[{"given":"Andrea","family":"Brenna","sequence":"first","affiliation":[{"name":"Pasteur Cenci Bolognetti Foundation, Department of Biology and Biotechnology \u201cCharles Darwin,\u201d Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Pasteur Cenci Bolognetti 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