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Here we use instantaneous interference with Arp2\/3 complex function in live fibroblasts with established lamellipodia. This allows direct examination of both the fate of elongating filaments upon instantaneous suppression of Arp2\/3 complex activity and the consequences of this treatment on the dynamics of other lamellipodial regulators. We show that Arp2\/3 complex is an essential organizer of treadmilling actin filament arrays but has little effect on the net rate of actin filament turnover at the cell periphery. In addition, Arp2\/3 complex serves as key upstream factor for the recruitment of modulators of lamellipodia formation such as capping protein or cofilin. Arp2\/3 complex is thus decisive for filament organization and geometry within the network not only by generating branches and novel filament ends, but also by directing capping or severing activities to the lamellipodium. Arp2\/3 complex is also crucial to lamellipodia-based migration of keratocytes.<\/jats:p>","DOI":"10.1091\/mbc.e12-12-0857","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T13:24:40Z","timestamp":1374758680000},"page":"2861-2875","source":"Crossref","is-referenced-by-count":80,"title":["Arp2\/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin"],"prefix":"10.1091","volume":"24","author":[{"given":"Stefan A.","family":"Koestler","sequence":"first","affiliation":[{"name":"Institute of Genetics, University of Bonn, D-53115 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Steffen","sequence":"additional","affiliation":[{"name":"Institute of Genetics, University of Bonn, D-53115 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nemethova","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biotechnology, Austrian Academy of Sciences, A-1030 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Winterhoff","sequence":"additional","affiliation":[{"name":"Institute for Biophysical Chemistry, Hannover Medical School, D-30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Genetics, University of Bonn, D-53115 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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