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Yeast Tip20, as a subunit of the Dsl1 complex, has been implicated in retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Our previous study showed that RINT-1, the mammalian counterpart of yeast Tip20, mediates the association of ZW10 (mammalian Dsl1) with endoplasmic reticulum\u2013localized SNARE proteins. In the present study, we show that RINT-1 is also required for endosome-to\u2013trans-Golgi network trafficking. RINT-1 uncomplexed with ZW10 interacts with the COG complex, another member of the CATCHR family complex, and regulates SNARE complex assembly at the trans-Golgi network. This additional role for RINT-1 may in part reflect adaptation to the demand for more diverse transport routes from endosomes to the trans-Golgi network in mammals compared with those in a unicellular organism, yeast. The present findings highlight a new role of RINT-1 in coordination with the COG complex.<\/jats:p>","DOI":"10.1091\/mbc.e13-01-0014","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T09:24:40Z","timestamp":1374744280000},"page":"2907-2917","source":"Crossref","is-referenced-by-count":20,"title":["A new role for RINT-1 in SNARE complex assembly at the\n                    <i>trans<\/i>\n                    -Golgi network in coordination with the COG complex"],"prefix":"10.1091","volume":"24","author":[{"given":"Kohei","family":"Arasaki","sequence":"first","affiliation":[{"name":"School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Takagi","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, 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