{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:48:51Z","timestamp":1793018931448,"version":"4.5.0"},"reference-count":58,"publisher":"American Society for Cell Biology (ASCB)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2014,2,15]]},"abstract":"<jats:p>\n                    Endoplasmic reticulum\u2013localized DnaJ 4 (ERdj4) is an immunoglobulin-binding protein (BiP) cochaperone and component of the endoplasmic reticulum\u2013associated degradation (ERAD) pathway that functions to remove unfolded\/misfolded substrates from the ER lumen under conditions of ER stress. To elucidate the function of ERdj4 in vivo, we disrupted the ERdj4 locus using gene trap (GT) mutagenesis, leading to hypomorphic expression of ERdj4 in mice homozygous for the trapped allele (ERdj4\n                    <jats:sup>GT\/GT<\/jats:sup>\n                    ). Approximately half of ERdj4\n                    <jats:sup>GT\/GT<\/jats:sup>\n                    mice died perinatally associated with fetal growth restriction, reduced hepatic glycogen stores, and hypoglycemia. Surviving adult mice exhibited evidence of constitutive ER stress in multiple cells\/tissues, including fibroblasts, lung, kidney, salivary gland, and pancreas. Elevated ER stress in pancreatic \u03b2 cells of ERdj4\n                    <jats:sup>GT\/GT<\/jats:sup>\n                    mice was associated with \u03b2 cell loss, hypoinsulinemia, and glucose intolerance. Collectively these results suggest an important role for ERdj4 in maintaining ER homeostasis during normal fetal growth and postnatal adaptation to metabolic stress.\n                  <\/jats:p>","DOI":"10.1091\/mbc.e13-06-0319","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:03:08Z","timestamp":1386806588000},"page":"431-440","source":"Crossref","is-referenced-by-count":54,"title":["Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects"],"prefix":"10.1091","volume":"25","author":[{"given":"Jill M.","family":"Fritz","sequence":"first","affiliation":[{"name":"Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, OH 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