{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:24:40Z","timestamp":1792711480225,"version":"4.5.0"},"reference-count":47,"publisher":"American Society for Cell Biology (ASCB)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p> Atmospheric gas plasmas (AGPs) are able to selectively induce apoptosis in cancer cells, offering a promising alternative to conventional therapies that have unwanted side effects such as drug resistance and toxicity. However, the mechanism of AGP-induced cancer cell death is unknown. In this study, AGP is shown to up-regulate intracellular reactive oxygen species (ROS) levels and induce apoptosis in melanoma but not normal melanocyte cells. By screening genes involved in apoptosis, we identify tumor necrosis factor (TNF)\u2013family members as the most differentially expressed cellular genes upon AGP treatment of melanoma cells. TNF receptor 1 (TNFR1) antagonist\u2013neutralizing antibody specifically inhibits AGP-induced apoptosis signal, regulating apoptosis signal\u2013regulating kinase 1 (ASK1) activity and subsequent ASK1-dependent apoptosis. Treatment of cells with intracellular ROS scavenger N-acetyl-l-cysteine also inhibits AGP-induced activation of ASK1, as well as apoptosis. Moreover, depletion of intracellular ASK1 reduces the level of AGP-induced oxidative stress and apoptosis. The evidence for TNF-signaling dependence of ASK1-mediated apoptosis suggests possible mechanisms for AGP activation and regulation of apoptosis-signaling pathways in tumor cells. <\/jats:p>","DOI":"10.1091\/mbc.e13-10-0590","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T22:16:10Z","timestamp":1393452970000},"page":"1523-1531","source":"Crossref","is-referenced-by-count":184,"title":["Atmospheric gas plasma\u2013induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis"],"prefix":"10.1091","volume":"25","author":[{"given":"Musarat","family":"Ishaq","sequence":"first","affiliation":[{"name":"CSIRO Materials Science and Engineering, North Ryde, NSW 1670, Australia"},{"name":"Plasma Nanoscience Center, CSIRO Materials Science and Engineering, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Plasma Nanoscience Center, CSIRO Materials Science and Engineering, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Varinli","sequence":"additional","affiliation":[{"name":"CSIRO Animal, Food and Health Sciences, North Ryde, NSW 1670, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao Jun","family":"Han","sequence":"additional","affiliation":[{"name":"Plasma Nanoscience Center, CSIRO Materials Science and Engineering, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda E.","family":"Rider","sequence":"additional","affiliation":[{"name":"Plasma Nanoscience Center, CSIRO Materials Science and Engineering, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret D. 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