{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:05:22Z","timestamp":1791407122633,"version":"4.3.3"},"reference-count":104,"publisher":"American Society for Cell Biology (ASCB)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Filopodia are long plasma membrane extensions involved in the formation of adhesive, contractile, and protrusive actin-based structures in spreading and migrating cells. Whether filopodia formed by different molecular mechanisms equally support these cellular functions is unresolved. We used Enabled\/vasodilator-stimulated phosphoprotein (Ena\/VASP)\u2013deficient MV<jats:sup>D7<\/jats:sup>fibroblasts, which are also devoid of endogenous mDia2, as a model system to investigate how these different actin regulatory proteins affect filopodia morphology and dynamics independently of one another. Filopodia initiated by either Ena\/VASP or mDia2 contained similar molecular inventory but differed significantly in parameters such as number, length, F-actin organization, lifetime, and protrusive persistence. Moreover, in the absence of Ena\/VASP, filopodia generated by mDia2 did not support initiation of integrin-dependent signaling cascades required for adhesion and subsequent lamellipodial extension, thereby causing a defect in early cell spreading. Coexpression of VASP with constitutively active mDia2<jats:sup>M\/A<\/jats:sup>rescued these early adhesion defects. We conclude that Ena\/VASP and mDia2 support the formation of filopodia with significantly distinct properties and that Ena\/VASP regulates mDia2-initiated filopodial morphology, dynamics, and function.<\/jats:p>","DOI":"10.1091\/mbc.e14-02-0712","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T07:53:20Z","timestamp":1404374000000},"page":"2604-2619","source":"Crossref","is-referenced-by-count":80,"title":["Ena\/VASP regulates mDia2-initiated filopodial length, dynamics, and function"],"prefix":"10.1091","volume":"25","author":[{"given":"Melanie","family":"Barzik","sequence":"first","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"McClain","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Gupton","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Gertler","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1074\/jbc.M006205200","volume":"276","author":"Alberts AS","year":"2001","journal-title":"J Biol Chem"},{"key":"B2","doi-asserted-by":"crossref","first-page":"e3234","DOI":"10.1371\/journal.pone.0003234","volume":"3","author":"Alexandrova AY","year":"2008","journal-title":"PloS One"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-11-0990"},{"key":"B4","doi-asserted-by":"crossref","first-page":"13298","DOI":"10.1073\/pnas.2336149100","volume":"100","author":"Arias-Salgado EG","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"B5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbamcr.2009.06.002","volume":"1803","author":"Aspenstr\u00f6m P","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"B6","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1093\/emboj\/19.18.4903","volume":"19","author":"Ball LJ","year":"2000","journal-title":"EMBO J"},{"key":"B7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1083\/jcb.200709029","volume":"181","author":"Bartolini F","year":"2008","journal-title":"J Cell Biol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"28653","DOI":"10.1074\/jbc.M503957200","volume":"280","author":"Barzik M","year":"2005","journal-title":"J Biol Chem"},{"key":"B9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(00)80884-3","volume":"101","author":"Bear JE","year":"2000","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0092-8674(02)00731-6","volume":"109","author":"Bear JE","year":"2002","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/ncb1745","volume":"10","author":"Beli P","year":"2008","journal-title":"Nat Cell Biol"},{"key":"B12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.devcel.2014.01.015","volume":"28","author":"Bilancia CG","year":"2014","journal-title":"Dev Cell"},{"key":"B13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2818.2008.02063.x","volume":"231","author":"Block J","year":"2008","journal-title":"J Microsc"},{"key":"B14","doi-asserted-by":"crossref","first-page":"12411","DOI":"10.1073\/pnas.0602443103","volume":"103","author":"Bohil AB","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0955-0674(99)00063-0","volume":"12","author":"Borisy GG","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"B16","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1038\/emboj.2008.211","volume":"27","author":"Breitsprecher D","year":"2008","journal-title":"EMBO J"},{"key":"B17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/emboj.2010.348","volume":"30","author":"Breitsprecher D","year":"2011","journal-title":"EMBO J"},{"key":"B18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ncb2205","volume":"13","author":"Burnette DT","year":"2011","journal-title":"Nat Cell Biol"},{"key":"B19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrm2867","volume":"11","author":"Campellone KG","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0960-9822(99)80315-7","volume":"9","author":"Carl UD","year":"1999","journal-title":"Curr Biol"},{"key":"B21","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1242\/jcs.109.8.2031","volume":"109","author":"Challacombe JF","year":"1996","journal-title":"J Cell Sci"},{"key":"B22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nrm2816","volume":"11","author":"Chesarone MA","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B23","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ncb1007-1110","volume":"9","author":"Chhabra ES","year":"2007","journal-title":"Nat Cell Biol"},{"key":"B24","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/361721a0","volume":"361","author":"Davenport RW","year":"1993","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/ncb1654","volume":"9","author":"Dent EW","year":"2007","journal-title":"Nat Cell Biol"},{"key":"B26","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1083\/jcb.105.6.2803","volume":"105","author":"DePasquale JA","year":"1987","journal-title":"J Cell Biol"},{"key":"B27","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1038\/emboj.2013.208","volume":"32","author":"Disanza A","year":"2013","journal-title":"EMBO J"},{"key":"B28","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.biocel.2009.02.012","volume":"41","author":"Faix J","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"B29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.200705002","volume":"179","author":"Furman C","year":"2007","journal-title":"J Cell Biol"},{"key":"B30","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1137904","volume":"315","author":"Galbraith CG","year":"2007","journal-title":"Science"},{"key":"B31","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1242\/dev.02849","volume":"134","author":"Gates J","year":"2007","journal-title":"Development"},{"key":"B32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","volume":"10","author":"Geiger B","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B33","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1083\/jcb.120.4.923","volume":"120","author":"Gittes F","year":"1993","journal-title":"J Cell Biol"},{"key":"B34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.biochem.75.103004.142647","volume":"76","author":"Goode BL","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"B35","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1093\/emboj\/cdg287","volume":"22","author":"Grosse R","year":"2003","journal-title":"EMBO J"},{"key":"B36","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.yexcr.2007.10.026","volume":"314","author":"Guillou H","year":"2008","journal-title":"Exp Cell Res"},{"key":"B37","doi-asserted-by":"crossref","first-page":"49877","DOI":"10.1074\/jbc.M209107200","volume":"277","author":"Han YH","year":"2002","journal-title":"J Biol Chem"},{"key":"B38","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1083\/jcb.201003014","volume":"191","author":"Hansen SD","year":"2010","journal-title":"J Cell Biol"},{"key":"B39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tibs.2005.04.014","volume":"30","author":"Higgs HN","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-02-0144"},{"key":"B41","doi-asserted-by":"crossref","first-page":"35761","DOI":"10.1074\/jbc.M106520200","volume":"276","author":"Hufner K","year":"2001","journal-title":"J Biol Chem"},{"key":"B42","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1083\/jcb.134.6.1551","volume":"134","author":"Huttenlocher A","year":"1996","journal-title":"J Cell Biol"},{"key":"B43","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","volume":"110","author":"Hynes RO","year":"2002","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0014-5793(99)00546-3","volume":"451","author":"H\u00fcttelmaier S","year":"1999","journal-title":"FEBS Lett"},{"key":"B45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-4889(02)00308-7","volume":"1592","author":"Katz BZ","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"B46","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1242\/jcs.03005","volume":"119","author":"Kovacs EM","year":"2006","journal-title":"J Cell Sci"},{"key":"B47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2005.11.038","volume":"124","author":"Kovar DR","year":"2006","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"crossref","first-page":"14725","DOI":"10.1073\/pnas.0405902101","volume":"101","author":"Kovar DR","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B49","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.devcel.2004.07.024","volume":"7","author":"Krause M","year":"2004","journal-title":"Dev Cell"},{"key":"B50","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/bies.10070","volume":"24","author":"Kureishy N","year":"2002","journal-title":"Bioessays"},{"key":"B51","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0092-8674(00)81280-5","volume":"84","author":"Lauffenburger DA","year":"1996","journal-title":"Cell"},{"key":"B52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0896-6273(04)00108-4","volume":"42","author":"Lebrand C","year":"2004","journal-title":"Neuron"},{"key":"B54","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0960-9822(03)00540-2","volume":"13","author":"Li F","year":"2003","journal-title":"Curr Biol"},{"key":"B55","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1074\/jbc.M411605200","volume":"280","author":"Li F","year":"2005","journal-title":"J Biol Chem"},{"key":"B53","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.cell.2007.05.041","volume":"129","author":"Lietha D","year":"2007","journal-title":"Cell"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e01-10-0102"},{"key":"B57","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.146.5.1097","volume":"146","author":"Mallavarapu A","year":"1999","journal-title":"J Cell Biol"},{"key":"B58","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2004.07.019","volume":"118","author":"Mejillano MR","year":"2004","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","volume":"6","author":"Mitra SK","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B60","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1016\/S0006-3495(96)79496-1","volume":"71","author":"Mogilner A","year":"1996","journal-title":"Biophys J"},{"key":"B61","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1529\/biophysj.104.056515","volume":"89","author":"Mogilner A","year":"2005","journal-title":"Biophys J"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-08-0621"},{"key":"B63","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1083\/jcb.200709134","volume":"180","author":"Nemethova M","year":"2008","journal-title":"J Cell Biol"},{"key":"B64","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1093\/emboj\/16.17.5433","volume":"16","author":"Niebuhr K","year":"1997","journal-title":"EMBO J"},{"key":"B65","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/35087035","volume":"3","author":"Palazzo AF","year":"2001","journal-title":"Nat Cell Biol"},{"key":"B66","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/jcs.00373","volume":"116","author":"Parsons JT","year":"2003","journal-title":"J Cell Sci"},{"key":"B67","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrm2957","volume":"11","author":"Parsons JT","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B68","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1038\/sj.onc.1203877","volume":"19","author":"Parsons JT","year":"2000","journal-title":"Oncogene"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-06-0496"},{"key":"B70","doi-asserted-by":"crossref","first-page":"9814","DOI":"10.1074\/jbc.M710475200","volume":"283","author":"Pasic L","year":"2008","journal-title":"J Biol Chem"},{"key":"B71","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/cm.20379","volume":"66","author":"Paul AS","year":"2009","journal-title":"Cell Motil Cytoskeleton"},{"key":"B72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cub.2005.01.011","volume":"15","author":"Pellegrin S","year":"2005","journal-title":"Curr Biol"},{"key":"B73","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0960-9822(03)00170-2","volume":"13","author":"Peng J","year":"2003","journal-title":"Curr Biol"},{"key":"B74","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1242\/jcs.113.18.3277","volume":"113","author":"Pistor S","year":"2000","journal-title":"J Cell Sci"},{"key":"B75","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1074\/jbc.R800043200","volume":"284","author":"Pollard TD","year":"2009","journal-title":"J Biol Chem"},{"key":"B76","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","volume":"112","author":"Pollard TD","year":"2003","journal-title":"Cell"},{"key":"B77","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1072309","volume":"297","author":"Pruyne D","year":"2002","journal-title":"Science"},{"key":"B78","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.106.3.747","volume":"106","author":"Rinnerthaler G","year":"1988","journal-title":"J Cell Biol"},{"key":"B79","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","volume":"97","author":"Rohatgi R","year":"1999","journal-title":"Cell"},{"key":"B86","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.yexcr.2008.11.008","volume":"315","author":"Sch\u00e4fer C","year":"2009","journal-title":"Exp Cell Res"},{"key":"B87","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4161\/cam.4.2.10745","volume":"4","author":"Sch\u00e4fer C","year":"2010","journal-title":"Cell Adh Migr"},{"key":"B80","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/MCB.14.3.1680","volume":"14","author":"Schaller MD","year":"1994","journal-title":"Mol Cell Biol"},{"key":"B81","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/embor.2013.49","volume":"14","author":"Schiller HB","year":"2013","journal-title":"EMBO Rep"},{"key":"B82","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1042\/BST0331256","volume":"33","author":"Schirenbeck A","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"B83","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.1073\/pnas.0511243103","volume":"103","author":"Schirenbeck A","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B84","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ncb1266","volume":"7","author":"Schirenbeck A","year":"2005","journal-title":"Nat Cell Biol"},{"key":"B85","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jcp.21772","volume":"220","author":"Schlegel N","year":"2009","journal-title":"J Cell Phys"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-01-0046"},{"key":"B89","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1083\/jcb.200106061","volume":"155","author":"Skoble J","year":"2001","journal-title":"J Cell Biol"},{"key":"B90","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0962-8924(01)02237-1","volume":"12","author":"Small JV","year":"2002","journal-title":"Trends Cell Biol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.8.2378"},{"key":"B92","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuron.2004.05.015","volume":"43","author":"Strasser GA","year":"2004","journal-title":"Neuron"},{"key":"B93","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200210174","volume":"160","author":"Svitkina TM","year":"2003","journal-title":"J Cell Biol"},{"key":"B94","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0092-8674(86)90744-0","volume":"46","author":"Tamkun JW","year":"1986","journal-title":"Cell"},{"key":"B95","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0962-8924(03)00153-3","volume":"13","author":"Wallar BJ","year":"2003","journal-title":"Trends Cell Biol"},{"key":"B96","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1074\/jbc.M510277200","volume":"281","author":"Wallar BJ","year":"2006","journal-title":"J Biol Chem"},{"key":"B97","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/11056","volume":"1","author":"Watanabe N","year":"1999","journal-title":"Nat Cell Biol"},{"key":"B98","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ncb1160","volume":"6","author":"Wen Y","year":"2004","journal-title":"Nat Cell Biol"},{"key":"B99","doi-asserted-by":"crossref","first-page":"15221","DOI":"10.1073\/pnas.93.26.15221","volume":"93","author":"Williamson T","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"B100","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1073\/pnas.1322093111","volume":"111","author":"Winkelman JD","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B101","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.123.3.653","volume":"123","author":"Wu D-Y","year":"1993","journal-title":"J Cell Biol"},{"key":"B102","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1371\/journal.pbio.0050317","volume":"5","author":"Yang C","year":"2007","journal-title":"PLoS Biol"},{"key":"B103","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1242\/jcs.00792","volume":"116","author":"Zaidel-Bar R","year":"2003","journal-title":"J Cell Sci"},{"key":"B104","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.cub.2003.09.057","volume":"13","author":"Zigmond SH","year":"2003","journal-title":"Curr Biol"}],"container-title":["Molecular Biology of the Cell"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T11:01:31Z","timestamp":1649588491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.molbiolcell.org\/doi\/10.1091\/mbc.e14-02-0712"}},"subtitle":[],"editor":[{"given":"Mark H.","family":"Ginsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":104,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1091\/mbc.e14-02-0712"],"URL":"https:\/\/doi.org\/10.1091\/mbc.e14-02-0712","relation":{},"ISSN":["1059-1524","1939-4586"],"issn-type":[{"value":"1059-1524","type":"print"},{"value":"1939-4586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}