{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:01:52Z","timestamp":1791295312049,"version":"4.1.0"},"reference-count":58,"publisher":"American Society for Cell Biology (ASCB)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:p>\n                    Like other eukaryotes, Saccharomyces cerevisiae spatially organizes its chromosomes within the nucleus. In G\n                    <jats:sub>1<\/jats:sub>\n                    phase, the yeast\u2019s 32 telomeres are clustered into 6\u201310 foci that dynamically interact with the nuclear membrane. Here we show that, when cells leave the division cycle and enter quiescence, telomeres gather into two to three hyperclusters at the nuclear membrane vicinity. This localization depends on Esc1 but not on the Ku proteins. Telomere hypercluster formation requires the Sir complex but is independent of the nuclear microtubule bundle that specifically assembles in quiescent cells. Importantly, mutants deleted for the linker histone H1 Hho1 or defective in condensin activity or affected for histone H4 Lys-16 deacetylation are impaired, at least in part, for telomere hypercluster formation in quiescence, suggesting that this process involves chromosome condensation. Finally, we establish that telomere hypercluster formation is not necessary for quiescence establishment, maintenance, and exit, raising the question of the physiological raison d\u2019\u00eatre of this nuclear reorganization.\n                  <\/jats:p>","DOI":"10.1091\/mbc.e16-01-0069","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T12:41:19Z","timestamp":1461847279000},"page":"1875-1884","source":"Crossref","is-referenced-by-count":61,"title":["Quiescent\n                    <i>Saccharomyces cerevisiae<\/i>\n                    forms telomere hyperclusters at the nuclear membrane vicinity through a multifaceted mechanism involving Esc1, the Sir complex, and chromatin condensation"],"prefix":"10.1091","volume":"27","author":[{"given":"Damien","family":"Laporte","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bordeaux\u2013Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, 33000 Bordeaux, France"},{"name":"CNRS\u2013UMR5095 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