{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:40:15Z","timestamp":1790743215024,"version":"4.1.0"},"reference-count":119,"publisher":"American Society for Cell Biology (ASCB)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Epithelial cells can acquire invasive and tumorigenic capabilities through epithelial\u2013mesenchymal-transition (EMT). The glycan-binding protein galectin-8 (Gal-8) activates selective \u03b21-integrins involved in EMT and is overexpressed by certain carcinomas. Here we show that Gal-8 overexpression or exogenous addition promotes proliferation, migration, and invasion in nontumoral Madin\u2013Darby canine kidney (MDCK) cells, involving focal-adhesion kinase (FAK)-mediated transactivation of the epidermal growth factor receptor (EGFR), likely triggered by \u03b15\u03b21integrin binding. Under subconfluent conditions, Gal-8\u2013overexpressing MDCK cells (MDCK-Gal-8<jats:sup>H<\/jats:sup>) display hallmarks of EMT, including decreased E-cadherin and up-regulated expression of vimentin, fibronectin, and Snail, as well as increased \u03b2-catenin activity. Changes related to migration\/invasion included higher expression of \u03b15\u03b21 integrin, extracellular matrix-degrading MMP13 and urokinase plasminogen activator\/urokinase plasminogen activator receptor (uPA\/uPAR) protease systems. Gal-8\u2013stimulated FAK\/EGFR pathway leads to proteasome overactivity characteristic of cancer cells. Yet MDCK-Gal-8<jats:sup>H<\/jats:sup>cells still develop apical\/basolateral polarity reverting EMT markers and proteasome activity under confluence. This is due to the opposite segregation of Gal-8 secretion (apical) and \u03b21-integrins distribution (basolateral). Strikingly, MDCK-Gal-8<jats:sup>H<\/jats:sup>cells acquired tumorigenic potential, as reflected in anchorage-independent growth in soft agar and tumor generation in immunodeficient NSG mice. Therefore, Gal-8 can promote oncogenic-like transformation of epithelial cells through partial and reversible EMT, accompanied by higher proliferation, migration\/invasion, and tumorigenic properties.<\/jats:p>","DOI":"10.1091\/mbc.e16-05-0301","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T17:23:26Z","timestamp":1515000206000},"page":"557-574","source":"Crossref","is-referenced-by-count":37,"title":["Galectin-8 induces partial epithelial\u2013mesenchymal transition with invasive tumorigenic capabilities involving a FAK\/EGFR\/proteasome pathway in Madin\u2013Darby canine kidney cells"],"prefix":"10.1091","volume":"29","author":[{"given":"Claudia","family":"Oyanadel","sequence":"first","affiliation":[{"name":"Centro de Biolog\u00eda Celular y Biomedicina (CEBICEM), Facultad de Medicina, Universidad San Sebasti\u00e1n, 7510156 Santiago, Chile"},{"name":"Fundaci\u00f3n Ciencia y Vida, 7780272 Santiago, 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