{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:30:44Z","timestamp":1791469844377,"version":"4.3.4"},"reference-count":48,"publisher":"American Society for Cell Biology (ASCB)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p> An intimate link between centrosome function and neurogenesis is revealed by the identification of many genes with centrosome-associated functions that are mutated in microcephaly disorders. Consistent with the major role of the centrosome in mitosis, mutations in these centrosome-related microcephaly (CRM) genes are thought to affect neurogenesis by depleting the pool of neural progenitor cells, primarily through apoptosis as a consequence of mitotic failure or premature differentiation as a consequence of cell cycle delay and randomization of spindle orientation. However, as suggested by the wide range of microcephaly phenotypes and the multifunctional nature of many CRM proteins, this picture of CRM gene function is incomplete. Here, we explore several examples of CRM genes pointing to additional functions that contribute to microcephaly, including regulation of cell cycle signaling, actin cytoskeleton, and Hippo pathway proteins, as well as functions in postmitotic neurons and glia. As these examples are likely just the tip of the iceberg, further exploration of the roles of microcephaly-related genes are certain to reveal additional unforeseen functions important for neurodevelopment. <\/jats:p>","DOI":"10.1091\/mbc.e17-03-0192","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T15:48:21Z","timestamp":1517586501000},"page":"241-246","source":"Crossref","is-referenced-by-count":41,"title":["Same but different: pleiotropy in centrosome-related microcephaly"],"prefix":"10.1091","volume":"29","author":[{"given":"Ryan S.","family":"O\u2019Neill","sequence":"first","affiliation":[{"name":"Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Schoborg","sequence":"additional","affiliation":[{"name":"Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser M.","family":"Rusan","sequence":"additional","affiliation":[{"name":"Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jmg.2009.076646","volume":"47","author":"Al-Dosari MS","year":"2010","journal-title":"J Med Genet"},{"key":"B2","doi-asserted-by":"crossref","first-page":"20130464","DOI":"10.1098\/rstb.2013.0464","volume":"369","author":"Arquint C","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"B3","doi-asserted-by":"crossref","first-page":"E1491","DOI":"10.1073\/pnas.1400568111","volume":"111","author":"Bazzi H","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature09327","volume":"467","author":"Bilg\u00fcvar K","year":"2010","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1242\/jcs.107326","volume":"125","author":"Bogoyevitch MA","year":"2012","journal-title":"J Cell Sci"},{"key":"B6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1539","volume":"37","author":"Bond J","year":"2005","journal-title":"Nat Genet"},{"key":"B7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.neuron.2010.03.036","volume":"66","author":"Buchman JJ","year":"2010","journal-title":"Neuron"},{"key":"B8","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.1038\/ncomms9763","volume":"6","author":"Capecchi MR","year":"2015","journal-title":"Nat Commun"},{"key":"B9","doi-asserted-by":"crossref","first-page":"11005","DOI":"10.1038\/ncomms11005","volume":"7","author":"Chavali PL","year":"2016","journal-title":"Nat Commun"},{"key":"B10","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1038\/ncomms4885","volume":"5","author":"Chen J-F","year":"2014","journal-title":"Nat Commun"},{"key":"B11","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1016\/j.celrep.2016.02.085","volume":"14","author":"Chou E-J","year":"2016","journal-title":"Cell Rep"},{"key":"B12","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","volume":"33","author":"Cunningham CL","year":"2013","journal-title":"J Neurosci"},{"key":"B13","author":"Duerinckx S","year":"2017","journal-title":"Semin Cell Dev Biol"},{"key":"B14","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1523\/JNEUROSCI.2359-16.2016","volume":"36","author":"Dwyer ND","year":"2016","journal-title":"J Neurosci"},{"key":"B15","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1073\/pnas.0604066103","volume":"103","author":"Fish JL","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-04-0371"},{"key":"B17","doi-asserted-by":"crossref","first-page":"803","DOI":"10.15252\/embj.201593679","volume":"35","author":"Gabriel E","year":"2016","journal-title":"EMBO J"},{"key":"B18","doi-asserted-by":"crossref","first-page":"12476","DOI":"10.1038\/ncomms12476","volume":"7","author":"Galletta BJ","year":"2016","journal-title":"Nat Commun"},{"key":"B19","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1038\/ncomms7474","volume":"6","author":"Garcez PP","year":"2015","journal-title":"Nat Commun"},{"key":"B20","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1242\/dev.080515","volume":"139","author":"Homem CCF","year":"2012","journal-title":"Development"},{"key":"B21","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/nn.3831","volume":"17","author":"Insolera R","year":"2014","journal-title":"Nat Neurosci"},{"key":"B22","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2016.09.056","volume":"92","author":"Jayaraman D","year":"2016","journal-title":"Neuron"},{"key":"B23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ejhg.2015.156","volume":"24","author":"Jouan L","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"B24","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/j.cub.2015.08.064","volume":"25","author":"Keder A","year":"2015","journal-title":"Curr Biol"},{"key":"B25","doi-asserted-by":"crossref","first-page":"e07519","DOI":"10.7554\/eLife.07519","volume":"4","author":"Kodani A","year":"2015","journal-title":"Elife"},{"key":"B26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","volume":"501","author":"Lancaster MA","year":"2013","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10577-015-9506-4","volume":"24","author":"Lerit DA","year":"2016","journal-title":"Chromosome Res"},{"key":"B28","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.stemcr.2017.08.013","volume":"9","author":"Li H","year":"2017","journal-title":"Stem Cell Rep"},{"key":"B29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.stemcr.2017.05.015","volume":"9","author":"Lim NR","year":"2017","journal-title":"Stem Cell Rep"},{"key":"B30","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1242\/dev.040410","volume":"137","author":"Lizarraga SB","year":"2010","journal-title":"Development"},{"key":"B31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-319-57127-0_2","volume":"1002","author":"Nano M","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"B32","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1083\/jcb.201607022","volume":"216","author":"Poulton JS","year":"2017","journal-title":"J Cell Biol"},{"key":"B33","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.celrep.2015.12.097","volume":"14","author":"Ramdas Nair A","year":"2016","journal-title":"Cell Rep"},{"key":"B34","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ncb2858","volume":"15","author":"Rujano MA","year":"2013","journal-title":"Nat Cell Biol"},{"key":"B35","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1083\/jcb.201509054","volume":"211","author":"Schoborg T","year":"2015","journal-title":"J Cell Biol"},{"key":"B36","doi-asserted-by":"crossref","first-page":"43708","DOI":"10.1038\/srep43708","volume":"7","author":"Sgourdou P","year":"2017","journal-title":"Sci Rep"},{"key":"B37","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.devcel.2016.04.024","volume":"37","author":"Sharma A","year":"2016","journal-title":"Dev Cell"},{"key":"B38","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00438-016-1277-x","volume":"292","author":"Sukumaran SK","year":"2017","journal-title":"Mol Genet Genom"},{"key":"B39","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1038\/emboj.2011.378","volume":"30","author":"Tang C-JC","year":"2011","journal-title":"EMBO J"},{"key":"B40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.tig.2009.09.011","volume":"25","author":"Thornton GK","year":"2009","journal-title":"Trends Genet"},{"key":"B41","doi-asserted-by":"crossref","first-page":"a025049","DOI":"10.1101\/cshperspect.a025049","volume":"8","author":"Vertii A","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B42","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.devcel.2011.08.002","volume":"21","author":"Wang C","year":"2011","journal-title":"Dev Cell"},{"key":"B43","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nature08435","volume":"461","author":"Wang X","year":"2009","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"crossref","first-page":"20130459","DOI":"10.1098\/rstb.2013.0459","volume":"369","author":"Woodruff JB","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"B45","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/mgg3.158","volume":"3","author":"Yigit G","year":"2015","journal-title":"Mol Genet Genom Med"},{"key":"B46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.210773.112","volume":"27","author":"Yu F-X","year":"2013","journal-title":"Genes Dev"},{"key":"B47","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","volume":"163","author":"Yu F-X","year":"2015","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"crossref","first-page":"E354","DOI":"10.1073\/pnas.1317535111","volume":"111","author":"Zheng X","year":"2014","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1091\/mbc.E17-03-0192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T13:10:12Z","timestamp":1563109812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.molbiolcell.org\/doi\/10.1091\/mbc.E17-03-0192"}},"subtitle":[],"editor":[{"given":"William","family":"Bement","sequence":"additional","affiliation":[{"name":"University of Wisconsin"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1091\/mbc.E17-03-0192"],"URL":"https:\/\/doi.org\/10.1091\/mbc.e17-03-0192","relation":{},"ISSN":["1059-1524","1939-4586"],"issn-type":[{"value":"1059-1524","type":"print"},{"value":"1939-4586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}