{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:03:54Z","timestamp":1790402634077,"version":"4.1.0"},"reference-count":104,"publisher":"American Society for Cell Biology (ASCB)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"<jats:p>In pancreatic \u03b2-cells, insulin granule membranes are enriched in cholesterol and are both recycled and newly generated. Cholesterol\u2019s role in supporting granule membrane formation and function is poorly understood. ATP binding cassette transporters ABCG1 and ABCA1 regulate intracellular cholesterol and are important for insulin secretion. RNAi inter\u00adference\u2013induced depletion in cultured pancreatic \u03b2-cells shows that ABCG1 is needed to stabilize newly made insulin granules against lysosomal degradation; ABCA1 is also involved but to a lesser extent. Both transporters are also required for optimum glucose-stimulated insulin secretion, likely via complementary roles. Exogenous cholesterol addition rescues knockdown-induced granule loss (ABCG1) and reduced secretion (both transporters). Another cholesterol transport protein, oxysterol binding protein (OSBP), appears to act proximally as a source of endogenous cholesterol for granule formation. Its knockdown caused similar defective stability of young granules and glucose-stimulated insulin secretion, neither of which were rescued with exogenous cholesterol. Dual knockdowns of OSBP and ABC transporters support their serial function in supplying and concentrating cholesterol for granule formation. OSBP knockdown also decreased proinsulin synthesis consistent with a proximal endoplasmic reticulum defect. Thus, membrane cholesterol distribution contributes to insulin homeostasis at production, packaging, and export levels through the actions of OSBP and ABCs G1 and A1.<\/jats:p>","DOI":"10.1091\/mbc.e17-08-0519","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T17:10:44Z","timestamp":1521047444000},"page":"1238-1257","source":"Crossref","is-referenced-by-count":37,"title":["Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP"],"prefix":"10.1091","volume":"29","author":[{"given":"Syed Saad","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan T.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J. B.","family":"Kreutzberger","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908"},{"name":"Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice M.","family":"Inouye","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Castle","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Arvan","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. David","family":"Castle","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"},{"name":"Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1083\/jcb.200506163","volume":"173","author":"Ahras M","year":"2006","journal-title":"J Cell Biol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"23110","DOI":"10.1074\/jbc.M115.655027","volume":"290","author":"Ansari I-UH","year":"2015","journal-title":"J Biol Chem"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-11-0758"},{"key":"B4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1600-0854.2010.01066.x","volume":"11","author":"B\u00e4ck N","year":"2010","journal-title":"Traffic"},{"key":"B5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0003-9861(85)90046-3","volume":"240","author":"Balch WE","year":"1985","journal-title":"Arch Biochem Biophys"},{"key":"B6","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1242\/jcs.01093","volume":"117","author":"Bauer RA","year":"2004","journal-title":"J Cell Sci"},{"key":"B7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1042\/bj3490843","volume":"349","author":"Blazquez M","year":"2000","journal-title":"Biochem J"},{"key":"B8","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","volume":"37","author":"Bligh EG","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"B10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nm1546","volume":"13","author":"Brunham LR","year":"2007","journal-title":"Nat Med"},{"key":"B11","doi-asserted-by":"crossref","first-page":"e1001541","DOI":"10.1371\/journal.pbio.1001541","volume":"11","author":"Cao M","year":"2013","journal-title":"PLoS Biol"},{"key":"B12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.cellbio.22.010305.104656","volume":"22","author":"Chang T-Y","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1600-0854.2010.01046.x","volume":"11","author":"Devlin C","year":"2010","journal-title":"Traffic"},{"key":"B15","doi-asserted-by":"crossref","first-page":"29887","DOI":"10.1074\/jbc.M005364200","volume":"275","author":"Dhanvantari S","year":"2000","journal-title":"J Biol Chem"},{"key":"B16","doi-asserted-by":"crossref","first-page":"e18134","DOI":"10.7554\/eLife.18134","volume":"5","author":"Du W","year":"2016","journal-title":"eLife"},{"key":"B17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature01389","volume":"422","author":"Duncan RR","year":"2003","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.200902095","volume":"186","author":"Edwards SL","year":"2009","journal-title":"J Cell Biol"},{"key":"B19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature14429","volume":"523","author":"Frechin M","year":"2015","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbalip.2011.07.012","volume":"1821","author":"Gao X","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"B21","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1126\/science.aaa2628","volume":"347","author":"Goginashvili A","year":"2015","journal-title":"Science"},{"key":"B22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","volume":"161","author":"Goldstein JL","year":"2015","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1242\/jcs.02906","volume":"119","author":"Gondre-Lewis MC","year":"2006","journal-title":"J Cell Sci"},{"key":"B24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1600-0854.2005.00258.x","volume":"6","author":"Grimmer SMY","year":"2005","journal-title":"Traffic"},{"key":"B25","doi-asserted-by":"crossref","first-page":"22025","DOI":"10.1074\/jbc.M201614200","volume":"277","author":"Grishanin RN","year":"2002","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1074\/jbc.M112.420018","volume":"288","author":"Haataja L","year":"2013","journal-title":"J Biol Chem"},{"key":"B27","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1016\/S0021-9258(18)43686-1","volume":"255","author":"Halban PA","year":"1980","journal-title":"J Biol Chem"},{"key":"B28","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1083\/jcb.200708018","volume":"180","author":"Hammarlund M","year":"2008","journal-title":"J Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E15-07-0487"},{"key":"B30","doi-asserted-by":"crossref","first-page":"e1002722","DOI":"10.1371\/journal.pgen.1002722","volume":"8","author":"Hannemann M","year":"2012","journal-title":"PLoS Genet"},{"key":"B31","doi-asserted-by":"crossref","first-page":"29489","DOI":"10.1074\/jbc.M109.038034","volume":"284","author":"Hao M","year":"2009","journal-title":"J Biol Chem"},{"key":"B32","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.2337\/db07-0056","volume":"56","author":"Hao M","year":"2007","journal-title":"Diabetes"},{"key":"B33","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2337\/diabetes.49.3.424","volume":"49","author":"Hohmeier HE","year":"2000","journal-title":"Diabetes"},{"key":"B34","doi-asserted-by":"crossref","first-page":"e1001542","DOI":"10.1371\/journal.pbio.1001542","volume":"11","author":"Holst B","year":"2013","journal-title":"PLoS Biol"},{"key":"B35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature13474","volume":"510","author":"Holthuis JCM","year":"2014","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1074\/jbc.M310104200","volume":"279","author":"Hosaka M","year":"2003","journal-title":"J Biol Chem"},{"key":"B37","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1242\/jcs.02608","volume":"118","author":"Hosaka M","year":"2005","journal-title":"J Cell Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e17-08-0491"},{"key":"B39","doi-asserted-by":"crossref","first-page":"e08009","DOI":"10.7554\/eLife.08009","volume":"4","author":"Ito A","year":"2015","journal-title":"eLife"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E15-07-0509"},{"key":"B41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.devcel.2013.09.016","volume":"27","author":"Kanerva K","year":"2013","journal-title":"Dev Cell"},{"key":"B42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1083\/jcb.200901145","volume":"185","author":"Klemm RW","year":"2009","journal-title":"J Cell Biol"},{"key":"B43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1083\/jcb.141.2.359","volume":"141","author":"Klumperman J","year":"1998","journal-title":"J Cell Biol"},{"key":"B44","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1194\/jlr.M500546-JLR200","volume":"47","author":"Kobayashi A","year":"2006","journal-title":"J Lipid Res"},{"key":"B45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bpj.2015.06.022","volume":"109","author":"Kreutzberger AJB","year":"2015","journal-title":"Biophys J"},{"key":"B46","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.2337\/db11-0081","volume":"60","author":"Kruit JK","year":"2011","journal-title":"Diabetes"},{"key":"B47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2337\/db11-1341","volume":"61","author":"Kruit JK","year":"2012","journal-title":"Diabetes"},{"key":"B48","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1083\/jcb.118.3.521","volume":"118","author":"Kuliawat R","year":"1992","journal-title":"J Cell Biol"},{"key":"B49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1083\/jcb.126.1.77","volume":"126","author":"Kuliawat R","year":"1994","journal-title":"J Cell Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-08-0554"},{"key":"B51","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1083\/jcb.201001164","volume":"190","author":"Liu Y","year":"2010","journal-title":"J Cell Biol"},{"key":"B52","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1210\/me.2007-0077","volume":"21","author":"Marsh BJ","year":"2007","journal-title":"Mol Endocrinol"},{"key":"B53","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1242\/jcs.195479","volume":"130","author":"Matsunaga K","year":"2017","journal-title":"J Cell Sci"},{"key":"B54","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/B978-0-12-386487-1.00017-1","volume":"108","author":"Maxfield FR","year":"2012","journal-title":"Methods Cell Biol"},{"key":"B55","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1007\/s00018-012-1247-3","volume":"70","author":"Mesmin B","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"B56","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.cell.2013.09.056","volume":"155","author":"Mesmin B","year":"2013","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.15252\/embj.201796687","volume":"36","author":"Mesmin B","year":"2017","journal-title":"EMBO J"},{"key":"B58","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bbalip.2009.03.002","volume":"1791","author":"Mesmin B","year":"2009","journal-title":"Mol Cell Biol Lipids"},{"key":"B59","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2337\/db06-0367","volume":"56","author":"Michael DJ","year":"2007","journal-title":"Diabetes"},{"key":"B60","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1034\/j.1600-0854.2003.00072.x","volume":"4","author":"Mobius W","year":"2003","journal-title":"Traffic"},{"key":"B61","doi-asserted-by":"crossref","first-page":"41748","DOI":"10.1074\/jbc.M105823200","volume":"276","author":"Nilsson I","year":"2001","journal-title":"J Biol Chem"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e13-05-0250"},{"key":"B63","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1177\/31.8.6134769","volume":"31","author":"Oliver C","year":"1983","journal-title":"J Histochem Cytochem"},{"key":"B64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1073\/pnas.78.1.293","volume":"78","author":"Orci L","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"B65","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1083\/jcb.98.1.222","volume":"98","author":"Orci L","year":"1984","journal-title":"J Cell Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-05-0498"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-01-0060"},{"key":"B68","doi-asserted-by":"crossref","first-page":"24020","DOI":"10.1074\/jbc.R114.583658","volume":"289","author":"Phillips MC","year":"2014","journal-title":"J Biol Chem"},{"key":"B69","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1242\/jcs.01055","volume":"117","author":"Pomorski T","year":"2004","journal-title":"J Cell Sci"},{"key":"B70","doi-asserted-by":"crossref","first-page":"34414","DOI":"10.1074\/jbc.M113.508812","volume":"288","author":"Quazi F","year":"2013","journal-title":"J Biol Chem"},{"key":"B71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1083\/jcb.105.1.145","volume":"105","author":"Rhodes CJ","year":"1987","journal-title":"J Cell Biol"},{"key":"B72","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1007\/s00125-016-3868-9","volume":"59","author":"Riahi Y","year":"2016","journal-title":"Diabetologia"},{"key":"B73","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1194\/jlr.D007336","volume":"51","author":"Robinet P","year":"2010","journal-title":"J Lipid Res"},{"key":"B74","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00125-003-1153-1","volume":"46","author":"Rorsman P","year":"2003","journal-title":"Diabetologia"},{"key":"B75","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1194\/jlr.M700139-JLR200","volume":"48","author":"Sano O","year":"2007","journal-title":"J Lipid Res"},{"key":"B76","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/aja.1001610106","volume":"161","author":"Sato T","year":"1981","journal-title":"Am J Anat"},{"key":"B77","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1073\/pnas.85.11.3865","volume":"85","author":"Schuit FC","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"B78","doi-asserted-by":"crossref","first-page":"e1003812","DOI":"10.1371\/journal.pgen.1003812","volume":"9","author":"Sirkis DW","year":"2013","journal-title":"PLoS Genet"},{"key":"B79","doi-asserted-by":"crossref","first-page":"29480","DOI":"10.1074\/jbc.M110.148254","volume":"285","author":"Sokolov A","year":"2010","journal-title":"J Biol Chem"},{"key":"B80","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/j.1460-2075.1996.tb00564.x","volume":"15","author":"Solimena M","year":"1996","journal-title":"EMBO J"},{"key":"B81","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cmet.2007.11.009","volume":"7","author":"Speidel D","year":"2008","journal-title":"Cell Metab"},{"issue":"1","key":"B82","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/bj3360247","volume":"336","author":"Storey MK","year":"1998","journal-title":"Biochem J"},{"key":"B83","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1172\/JCI41280","volume":"120","author":"Sturek JM","year":"2010","journal-title":"J Clin Invest"},{"key":"B84","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1083\/jcb.200902096","volume":"186","author":"Sumakovic M","year":"2009","journal-title":"J Cell Biol"},{"key":"B85","doi-asserted-by":"crossref","first-page":"19719","DOI":"10.1073\/pnas.1113021108","volume":"108","author":"Tarling EJ","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B86","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbalip.2011.07.011","volume":"1821","author":"Tarling EJ","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"B87","doi-asserted-by":"crossref","first-page":"e1006074","DOI":"10.1371\/journal.pgen.1006074","volume":"12","author":"Topalidou I","year":"2016","journal-title":"PLoS Genet"},{"key":"B88","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1210\/en.2010-0623","volume":"151","author":"Tsuchiya M","year":"2010","journal-title":"Endocrinology"},{"key":"B89","first-page":"14225","volume":"275","author":"Turner MD","year":"2000","journal-title":"J Biol Chem"},{"key":"B90","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","volume":"9","author":"van Meer G","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B91","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1194\/jlr.M300078-JLR200","volume":"44","author":"Vaughan AM","year":"2003","journal-title":"J Lipid Res"},{"key":"B92","doi-asserted-by":"crossref","first-page":"30150","DOI":"10.1074\/jbc.M505368200","volume":"280","author":"Vaughan AM","year":"2005","journal-title":"J Biol Chem"},{"key":"B93","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.bbrc.2004.09.147","volume":"324","author":"Vo YP","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"B94","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.15252\/embj.201387549","volume":"33","author":"Walter AM","year":"2014","journal-title":"EMBO J"},{"key":"B95","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1172\/JCI32057","volume":"117","author":"Wang X","year":"2007","journal-title":"J Clin Invest"},{"key":"B96","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1034\/j.1600-0854.2000.011205.x","volume":"1","author":"Wang Y","year":"2000","journal-title":"Traffic"},{"key":"B97","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1600-0854.2005.00292.x","volume":"6","author":"Wasmeier C","year":"2005","journal-title":"Traffic"},{"key":"B98","doi-asserted-by":"crossref","first-page":"18162","DOI":"10.1074\/jbc.271.30.18161","volume":"271","author":"Wasmeier C","year":"1996","journal-title":"J Biol Chem"},{"key":"B99","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1749-6632.1987.tb27186.x","volume":"493","author":"Westhead EW","year":"1987","journal-title":"Ann NY Acad Sci"},{"key":"B100","doi-asserted-by":"crossref","first-page":"42080","DOI":"10.1074\/jbc.M303509200","volume":"278","author":"Wicksteed B","year":"2003","journal-title":"J Biol Chem"},{"key":"B101","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1210\/en.2008-0161","volume":"149","author":"Xia F","year":"2008","journal-title":"Endocrinology"},{"key":"B102","doi-asserted-by":"crossref","first-page":"23464","DOI":"10.1074\/jbc.M115.662668","volume":"290","author":"Yamauchi Y","year":"2015","journal-title":"J Biol Chem"},{"key":"B103","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/340075a0","volume":"340","author":"Zachowski A","year":"1989","journal-title":"Nature"},{"key":"B104","volume":"4","author":"Zhang X","year":"2017","journal-title":"J Cell Biol"},{"key":"B105","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2337\/db15-1264","volume":"65","author":"Zhu S","year":"2016","journal-title":"Diabetes"},{"key":"B106","doi-asserted-by":"crossref","first-page":"22930","DOI":"10.1074\/jbc.M801408200","volume":"283","author":"Zhu X","year":"2008","journal-title":"J Biol Chem"}],"container-title":["Molecular Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1091\/mbc.E17-08-0519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T01:18:39Z","timestamp":1660612719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.molbiolcell.org\/doi\/10.1091\/mbc.E17-08-0519"}},"subtitle":[],"editor":[{"given":"Adam","family":"Linstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":104,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,5,15]]}},"alternative-id":["10.1091\/mbc.E17-08-0519"],"URL":"https:\/\/doi.org\/10.1091\/mbc.e17-08-0519","relation":{},"ISSN":["1059-1524","1939-4586"],"issn-type":[{"value":"1059-1524","type":"print"},{"value":"1939-4586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]}}}