{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:36:53Z","timestamp":1792679813972,"version":"4.5.0"},"reference-count":73,"publisher":"American Society for Cell Biology (ASCB)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Pathogen-induced host plasma membrane damage is a recently recognized mechanism used by pathogens to promote their entry into host cells. We identified key transducers activated upon host cell perforation by the pore-forming toxin LLO to promote Listeria entry. This pathway is distinct from the pathway that reseals the toxin-perforated cell.<\/jats:p>","DOI":"10.1091\/mbc.e17-09-0561","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:10:18Z","timestamp":1511975418000},"page":"270-284","source":"Crossref","is-referenced-by-count":33,"title":["Host cell perforation by listeriolysin O (LLO) activates a Ca<sup>2+<\/sup>-dependent cPKC\/Rac1\/Arp2\/3 signaling pathway that promotes<i>Listeria monocytogenes<\/i>internalization independently of membrane resealing"],"prefix":"10.1091","volume":"29","author":[{"given":"Jonathan G. T.","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210"},{"name":"Department of Microbiology, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Vadia","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarika","family":"Pathak-Sharma","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5624"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Seveau","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210"},{"name":"Department of Microbiology, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.tcb.2014.07.008","volume":"24","author":"Andrews NW","year":"2014","journal-title":"Trends Cell Biol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.chembiol.2014.02.008","volume":"21","author":"Antal CE","year":"2014","journal-title":"Chem Biol"},{"key":"B3","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1371\/journal.pbio.0040162","volume":"4","author":"Beemiller P","year":"2006","journal-title":"PLoS Biol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","volume":"275","author":"Bergelson JM","year":"1997","journal-title":"Science"},{"key":"B5","doi-asserted-by":"crossref","first-page":"e00087-17","DOI":"10.1128\/IAI.00087-17","volume":"85","author":"Bhalla M","year":"2017","journal-title":"Infect Immun"},{"key":"B6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1462-5822.2003.00273.x","volume":"5","author":"Brumell JH","year":"2003","journal-title":"Cell Microbiol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ceb.2008.12.001","volume":"21","author":"Chesarone MA","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1152\/physrev.00037.2014","volume":"95","author":"Cooper ST","year":"2015","journal-title":"Physiol Rev"},{"key":"B9","doi-asserted-by":"crossref","first-page":"e00926","DOI":"10.7554\/eLife.00926","volume":"2","author":"Corrotte M","year":"2013","journal-title":"Elife"},{"key":"B10","doi-asserted-by":"crossref","first-page":"a016972","DOI":"10.1101\/cshperspect.a016972","volume":"6","author":"Cossart P","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","volume":"304","author":"Cossart P","year":"2004","journal-title":"Science"},{"key":"B12","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1084\/jem.186.9.1487","volume":"186","author":"Cox D","year":"1997","journal-title":"J Exp Med"},{"key":"B13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2958.1995.tb02297.x","volume":"16","author":"Dramsi S","year":"1995","journal-title":"Mol Microbiol"},{"key":"B14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","volume":"420","author":"Etienne-Manneville S","year":"2002","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1084\/jem.20102518","volume":"208","author":"Fernandes MC","year":"2011","journal-title":"J Exp Med"},{"key":"B16","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/cmi.12090","volume":"15","author":"Fernandes MC","year":"2013","journal-title":"Cell Microbiol"},{"key":"B17","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0092-8674(91)90009-N","volume":"65","author":"Gaillard JL","year":"1991","journal-title":"Cell"},{"key":"B18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.chom.2009.04.008","volume":"5","author":"Galan JE","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-61779-160-4_17","volume":"756","author":"Gallegos LL","year":"2011","journal-title":"Methods Mol Biol"},{"key":"B20","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/IAI.68.2.999-1003.2000","volume":"68","author":"Gedde MM","year":"2000","journal-title":"Infect Immun"},{"key":"B21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.20141406","volume":"212","author":"Gessain G","year":"2015","journal-title":"J Exp Med"},{"key":"B22","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1462-5822.2011.01600.x","volume":"13","author":"Gonzalez MR","year":"2011","journal-title":"Cell Microbiol"},{"key":"B23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jcp.24110","volume":"228","author":"Gonzalez-Garcia JR","year":"2013","journal-title":"J Cell Physiol"},{"key":"B24","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00018-008-7578-4","volume":"65","author":"Groves E","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"B25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jim.2009.11.013","volume":"352","author":"Haghighat AC","year":"2010","journal-title":"J Immunol Methods"},{"issue":"5","key":"B26","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/BST0330891","volume":"33","author":"Hall A","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"B27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nrmicro2602","volume":"9","author":"Ham H","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"B28","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrmicro1413","volume":"4","author":"Hamon M","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"B29","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.chembiol.2013.03.019","volume":"20","author":"Hetrick B","year":"2013","journal-title":"Chem Biol"},{"key":"B30","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1016\/S0006-3495(02)75365-4","volume":"83","author":"Hoppe A","year":"2002","journal-title":"Biophys J"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-11-0847"},{"key":"B32","doi-asserted-by":"crossref","first-page":"8261","DOI":"10.1074\/jbc.M009865200","volume":"276","author":"Hotze EM","year":"2001","journal-title":"J Biol Chem"},{"key":"B33","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.200708010","volume":"180","author":"Idone V","year":"2008","journal-title":"J Cell Biol"},{"key":"B34","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1073\/pnas.0608213104","volume":"104","author":"Iliev AI","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B35","first-page":"73","volume":"7","author":"Isberg RR","year":"1990","journal-title":"Mol Biol Med"},{"key":"B36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ceb.2017.03.011","volume":"47","author":"Jimenez AJ","year":"2017","journal-title":"Curr Opin Cell Biol"},{"key":"B37","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.1128\/JVI.72.11.8806-8812.1998","volume":"72","author":"Li E","year":"1998","journal-title":"J Virol"},{"key":"B38","doi-asserted-by":"crossref","first-page":"9417","DOI":"10.1128\/JVI.01488-15","volume":"89","author":"Loustalot F","year":"2015","journal-title":"J Virol"},{"key":"B39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.chom.2015.06.006","volume":"18","author":"Luisoni S","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fimmu.2012.00361","volume":"3","author":"Maeda FY","year":"2012","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fcimb.2016.00035","volume":"6","author":"Mellouk N","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"B42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0092-8674(00)81070-3","volume":"84","author":"Mengaud J","year":"1996","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.mib.2012.05.016","volume":"15","author":"Mercer J","year":"2012","journal-title":"Curr Opin Microbiol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-12-0851"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0222","volume":"372","author":"Osborne SE","year":"2017","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"B46","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3389\/fcimb.2017.00305","volume":"7","author":"Pathak-Sharma S","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"B47","doi-asserted-by":"crossref","first-page":"e1000900","DOI":"10.1371\/journal.ppat.1000900","volume":"6","author":"Pentecost M","year":"2010","journal-title":"PLoS Pathog"},{"key":"B48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.semcdb.2016.07.019","volume":"60","author":"Pizarro-Cerda J","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"B49","doi-asserted-by":"crossref","first-page":"39413","DOI":"10.1074\/jbc.M302083200","volume":"278","author":"Price LS","year":"2003","journal-title":"J Biol Chem"},{"key":"B50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.micinf.2015.01.004","volume":"17","author":"Ribet D","year":"2015","journal-title":"Microbes Infect"},{"key":"B51","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/j.1462-5822.2008.01191.x","volume":"10","author":"Rosado CJ","year":"2008","journal-title":"Cell Microbiol"},{"key":"B52","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/cr.2010.45","volume":"20","author":"Rosselin M","year":"2010","journal-title":"Cell Res"},{"key":"B53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/imr.12118","volume":"256","author":"Rougerie P","year":"2013","journal-title":"Immunol Rev"},{"key":"B54","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-94-017-8881-6_9","volume":"80","author":"Seveau S","year":"2014","journal-title":"Subcell Biochem"},{"key":"B55","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1083\/jcb.200406078","volume":"166","author":"Seveau S","year":"2004","journal-title":"J Cell Biol"},{"key":"B56","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.micinf.2007.05.004","volume":"9","author":"Seveau S","year":"2007","journal-title":"Microbes Infect"},{"key":"B57","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1111\/j.1462-5822.2007.00903.x","volume":"9","author":"Shaughnessy LM","year":"2007","journal-title":"Cell Microbiol"},{"key":"B58","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0092-8674(00)00141-0","volume":"103","author":"Shen Y","year":"2000","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-08-0634"},{"issue":"5","key":"B60","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/jcs.064964","volume":"124","author":"Sit ST","year":"2011","journal-title":"J Cell Sci"},{"key":"B61","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1038\/cti.2016.15","volume":"5","author":"Stow JL","year":"2016","journal-title":"Clin Transl Immunology"},{"key":"B62","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1348-0421.2005.tb03647.x","volume":"49","author":"Sukeno A","year":"2005","journal-title":"Microbiol Immunol"},{"key":"B63","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1083\/jcb.201003053","volume":"189","author":"Tam C","year":"2010","journal-title":"J Cell Biol"},{"key":"B64","doi-asserted-by":"crossref","first-page":"e1002356","DOI":"10.1371\/journal.ppat.1002356","volume":"7","author":"Vadia S","year":"2011","journal-title":"PLoS Pathog"},{"key":"B65","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1128\/IAI.01067-13","volume":"82","author":"Vadia S","year":"2014","journal-title":"Infect Immun"},{"key":"B66","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1101\/gad.11.18.2295","volume":"11","author":"Van Aelst L","year":"1997","journal-title":"Genes Dev"},{"key":"B67","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1128\/CMR.14.3.584-640.2001","volume":"14","author":"Vazquez-Boland JA","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"B68","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/mbo3.28","volume":"1","author":"Velge P","year":"2012","journal-title":"Microbiologyopen"},{"key":"B69","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1083\/jcb.200302125","volume":"161","author":"Violin JD","year":"2003","journal-title":"J Cell Biol"},{"key":"B70","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1128\/JVI.72.4.3455-3458.1998","volume":"72","author":"Wang K","year":"1998","journal-title":"J Virol"},{"key":"B71","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1096\/fj.201600701R","volume":"30","author":"Wiedemann A","year":"2016","journal-title":"FASEB J"},{"key":"B72","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1462-5822.2004.00405.x","volume":"6","author":"Woolsey AM","year":"2004","journal-title":"Cell Microbiol"},{"key":"B73","author":"Yousuf MA","year":"2016","journal-title":"Biochemistry"}],"container-title":["Molecular Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1091\/mbc.E17-09-0561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T05:22:22Z","timestamp":1603430542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.molbiolcell.org\/doi\/10.1091\/mbc.E17-09-0561"}},"subtitle":[],"editor":[{"given":"William","family":"Bement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1091\/mbc.E17-09-0561"],"URL":"https:\/\/doi.org\/10.1091\/mbc.e17-09-0561","relation":{},"ISSN":["1059-1524","1939-4586"],"issn-type":[{"value":"1059-1524","type":"print"},{"value":"1939-4586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}