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Here we show that SUN2-null mice display cardiac hypertrophy coincident with enhanced AKT\/MAPK signaling, as has been described previously for mice lacking A-type lamins. Surprisingly, in contrast to lamin A\/C-null mice, SUN2-null mice fail to show coincident fibrosis or upregulation of pathological hypertrophy markers. Thus, cardiac hypertrophy is uncoupled from profibrotic signaling in this mouse model, which we tie to a requirement for the LINC complex in productive TGF\u03b2 signaling. In the absence of SUN2, we detect elevated levels of the integral inner nuclear membrane protein MAN1, an established negative regulator of TGF\u03b2 signaling, at the nuclear envelope. We suggest that A-type lamins and SUN2 play antagonistic roles in the modulation of profibrotic signaling through opposite effects on MAN1 levels at the nuclear lamina, suggesting a new perspective on disease etiology.<\/jats:p>","DOI":"10.1091\/mbc.e18-07-0438","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T13:38:12Z","timestamp":1557927492000},"page":"1664-1675","source":"Crossref","is-referenced-by-count":37,"title":["Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis"],"prefix":"10.1091","volume":"30","author":[{"given":"Rachel M.","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Yale School of Medicine, New Haven, CT 06520-8002"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa C.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Yale School of Medicine, New Haven, CT 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