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We show that dynamin 2, whose mutations cause centronuclear myopathy (CNM), regulates both clathrin plaques and surrounding branched actin filaments, while CNM-causing mutations lead to desmin disorganization in a CNM mouse model and patient biopsies. Our results suggest a novel paradigm in cell biology, wherein clathrin plaques act as platforms capable of recruiting branched cortical actin, which in turn anchors IFs, both essential for striated muscle formation and function.<\/jats:p>","DOI":"10.1091\/mbc.e18-11-0718","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T17:18:49Z","timestamp":1546449529000},"page":"579-590","source":"Crossref","is-referenced-by-count":57,"title":["Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle"],"prefix":"10.1091","volume":"30","author":[{"given":"Agathe","family":"Franck","sequence":"first","affiliation":[{"name":"Center of Research in Myology, Institute of Myology, UMRS 974, INSERM, Sorbonne Universit\u00e9, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Lain\u00e9","sequence":"additional","affiliation":[{"name":"Center of Research in Myology, Institute of Myology, 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