{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:27:19Z","timestamp":1790969239570,"version":"4.1.0"},"reference-count":67,"publisher":"American Society for Cell Biology (ASCB)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:p>Using CRISPRi-based depletion in human iPSC-derived neurons we demonstrate that AP-4 adaptor protein complex regulates neuronal lysosome composition and function via regulating sorting of critical lysosomal protein receptors including Sortilin 1 to the organelle. AP-4 also regulates axonal endo-lysosome abundance in these human neurons.<\/jats:p>","DOI":"10.1091\/mbc.e21-09-0473","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T11:54:03Z","timestamp":1660737243000},"source":"Crossref","is-referenced-by-count":24,"title":["AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network"],"prefix":"10.1091","volume":"33","author":[{"given":"Piyali","family":"Majumder","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Edmison","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Rodger","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sruchi","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Gowrishankar","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.73"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.019"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.5.923"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.179374"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.10.016"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.01.015"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.021"},{"key":"B8","first-page":"481","volume":"24","author":"Canuel M","year":"2009","journal-title":"Histol Histopathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4161\/pri.26746"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2425-12.2013"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1593"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201711083"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201412046"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12469"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06172-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.7278"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112295200"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007363"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38561"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11020152"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/cpcb.51"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.170217"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E20-06-0382"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201612148"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510329112"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2371-12.2013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu740"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.8.2787"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12028"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.19760"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.034"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.196196"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1615302"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25481"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100857200"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2019.00025"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202002084"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0196-6"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109034"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201106120"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.063636"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2571"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717327114"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-11-0658"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2011.01203.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.082263"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.9.2180"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802721200"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201805016"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-09-0746"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.12.008"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700217-MCP200"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02945-x"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00402-7"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.10.012"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.034"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2745"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.07.014"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36514"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.004"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.067686"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.08.019"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03468-5"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063049"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201711039"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03172"}],"container-title":["Molecular Biology of the Cell"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T15:53:39Z","timestamp":1663862019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.molbiolcell.org\/doi\/10.1091\/mbc.E21-09-0473"}},"subtitle":[],"editor":[{"given":"Michael","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":67,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,10,1]]}},"alternative-id":["10.1091\/mbc.E21-09-0473"],"URL":"https:\/\/doi.org\/10.1091\/mbc.e21-09-0473","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.25.449958","asserted-by":"object"}]},"ISSN":["1059-1524","1939-4586"],"issn-type":[{"value":"1059-1524","type":"print"},{"value":"1939-4586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]},"article-number":"ar102"}}