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Focusing on adenoviruses, influenza, rhinoviruses, RSV, and SARS-CoV-2, we explore a series of molecular case studies that reveal both shared strategies and the diverse molecular innovations these respiratory pathogens use to subvert the nuclear transport machinery. We organize these tactics into six recurring strategies: NPC docking and nuclear entry, inhibition of immune-factor import, hijacking nuclear protein transport and karyopherins, sabotage of host mRNA export, degradation of FG-Nups, and exploitation of mitotic nuclear envelope breakdown. These insights not only illuminate fundamental virus\u2013host conflicts but may also point the way toward new therapeutic vulnerabilities in the viruses\u2019 attack strategies.<\/jats:p>","DOI":"10.1091\/mbc.e25-07-0322","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T17:44:16Z","timestamp":1762969456000},"source":"Crossref","is-referenced-by-count":0,"title":["Breaking barriers: Respiratory viral strategies targeting the host's nuclear pore complex and nuclear transport pathways"],"prefix":"10.1091","volume":"37","author":[{"given":"Yael","family":"Udi","sequence":"first","affiliation":[{"name":"Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Aitchison","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 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