{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:39:50Z","timestamp":1793378390502,"version":"4.5.0"},"reference-count":52,"publisher":"American Society for Cell Biology (ASCB)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Adherens junctions (AJs) play a fundamental role in epithelial physiology, supporting cell-cell cohesion and communication. There has been a long-standing concept that loss of functioning AJs may contribute to epithelial inflammation. In the context of the intestine, experimental disruption of the E-cadherin adhesion system induces inflammation, while E-cadherin and its regulators have been identified as susceptibility genes for inflammatory bowel disease. In this article, we briefly consider how AJ dysfunction may serve as a driver in the pathogenesis of IBD, especially in light of emerging evidence that AJs can regulate intrinsic inflammatory programs in the intestinal epithelium.<\/jats:p>","DOI":"10.1091\/mbc.e25-09-0426","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:07:46Z","timestamp":1788365266000},"source":"Crossref","is-referenced-by-count":0,"title":["Adherens junction dysfunction in intestinal inflammation revisited"],"prefix":"10.1091","volume":"37","author":[{"given":"Fabienne","family":"Haslam","sequence":"first","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia 4072"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Begun","sequence":"additional","affiliation":[{"name":"Mater Research \u2013 The University of Queensland, Woolloongabba, QLD, Australia 4102"},{"name":"Department of Gastroenterology, Mater Hospital Brisbane, South Brisbane, Australia 4101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpha S.","family":"Yap","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia 4072"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2021.1940741"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12448"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/372190a0"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.22"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7563.340"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.483"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.18936"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100381"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2025.101682"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.043"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03836.x"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaf043"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.01.003"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.08.009"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327845"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5239.1203"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-6-883"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2025.2484494"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39401-0"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2004.02.034"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr8753"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.17.8263"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3136"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.101423"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108053"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-090222-100246"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.02.057"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38539"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.1800027"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan0814"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.175117"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1554"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.4.1645"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4246"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.17.4973"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00699-6"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.11.043"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163591"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2021.100332"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217220"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00587-5"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E26-01-0040"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014325"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.04.020"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41414"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038441"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600605"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103068"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86282"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00395-z"}],"container-title":["Molecular Biology of the Cell"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:58:01Z","timestamp":1793375881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.molbiolcell.org\/doi\/10.1091\/mbc.E25-09-0426"}},"subtitle":[],"editor":[{"given":"Jeff","family":"Hardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1091\/mbc.E25-09-0426"],"URL":"https:\/\/doi.org\/10.1091\/mbc.e25-09-0426","relation":{},"ISSN":["1059-1524","1939-4586"],"issn-type":[{"value":"1059-1524","type":"print"},{"value":"1939-4586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"re10"}}