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Vimentin knockdown delays wound closure and reduces cell coordination, while increasing traction forces exerted by cells on the substratum. It also disrupts the directionality of leader cell migration, as well as the cohesion and coordinated motion of cells deep in the monolayer. We further show that vimentin promotes the conversion of polarized cell locomotion into coordinated collective migration by polarizing actin, focal adhesions, and traction forces, sustaining leader cells\u2019 lamellipodium protrusive activity and directionality, while allowing mechanical coupling of leader with follower cells. Altogether, we show that vimentin is essential for bridging polarized single-cell locomotion and coordinated collective migration to allow efficient collective migration.<\/jats:p>","DOI":"10.1091\/mbc.e26-01-0052","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:17:53Z","timestamp":1785957473000},"source":"Crossref","is-referenced-by-count":0,"title":["Vimentin bridges scales to convert polarized cell locomotion into coordinated collective migration"],"prefix":"10.1091","volume":"37","author":[{"given":"Sudheer Kumar","family":"Peneti","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish Babu","family":"Moparthi","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institute of Myology, Centre of Research in Myology, UMRS 974, Paris, 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