{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:39:50Z","timestamp":1793378390450,"version":"4.5.0"},"reference-count":82,"publisher":"American Society for Cell Biology (ASCB)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBoC"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>\n                    Messenger RNAs (mRNAs) accumulate at centrosomes in mitosis and interphase, yet the mechanisms governing their localization and their functional significance remain poorly understood. Here, we identify a centriolar satellite\u2014RNA-binding protein (RBP) pathway that regulates\n                    <jats:italic toggle=\"yes\">CEP350<\/jats:italic>\n                    mRNA localization and stability to support centriole overduplication. We find that\n                    <jats:italic toggle=\"yes\">CEP350<\/jats:italic>\n                    mRNA localizes to centrosomes in S phase in a microtubule (MT)-dependent manner. The RBP Unkempt (UNK) and centriolar satellite protein CEP131, stabilize\n                    <jats:italic toggle=\"yes\">CEP350<\/jats:italic>\n                    mRNA and promote its steady-state levels and centrosomal protein accumulation. CEP350 is required for PLK4-induced centriole overduplication but has limited effects on canonical centriole duplication. Disrupting the centriolar satellite\u2014RBP pathway reduces centriole overduplication in triple-negative breast cancer cells, indicating CEP131 and UNK are potential therapeutic targets for reducing centriole overduplication.\n                  <\/jats:p>","DOI":"10.1091\/mbc.e26-03-0142","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T19:17:53Z","timestamp":1785957473000},"source":"Crossref","is-referenced-by-count":0,"title":["Centriolar satellites regulate\n                    <i>CEP350<\/i>\n                    mRNA stability and centrosome amplification"],"prefix":"10.1091","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1915-6593","authenticated-orcid":false,"given":"Abraham","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad G.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1076","reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac763"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000679"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkag229"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.039"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.097"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.11.042"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00490-5"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt015"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E23-11-0419"},{"key":"e_1_3_4_11_1","unstructured":"ClinicalTrials.gov (2026). 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