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This correlates with a highly inefficient apical retention of enzymes and transporters that accumulate in subapical endocytic compartments. Myosin-1a, a motor involved in the anchorage of membrane proteins in microvilli, is also mislocalized. These findings illustrate, in vivo, a precise role for local actin filament architecture in the stabilization of apical cargoes into microvilli. Hence, the function of actin-bundling proteins is not to enable microvillar protrusion, as has been assumed, but to confer the appropriate actin organization for the apical retention of proteins essential for normal intestinal physiology.<\/jats:p>","DOI":"10.1091\/mbc.e11-09-0765","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T05:55:38Z","timestamp":1322114138000},"page":"324-336","source":"Crossref","is-referenced-by-count":67,"title":["A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins"],"prefix":"10.1091","volume":"23","author":[{"given":"C\u00e9line","family":"Revenu","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 144, Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris, Cedex 05, France"}]},{"given":"Florent","family":"Ubelmann","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 144, Centre National de la Recherche 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