{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:57:23Z","timestamp":1775267843919,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":3342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1093\/annonc\/mdq439","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T05:51:05Z","timestamp":1282110665000},"page":"1931-1934","source":"Crossref","is-referenced-by-count":45,"title":["The prognostic significance of p16 overexpression in oropharyngeal squamous cell carcinoma: implications for treatment strategies and future clinical studies"],"prefix":"10.1016","volume":"21","author":[{"given":"J.A.","family":"Langendijk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Psyrri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1093\/annonc\/mdq439_bb0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1093\/annonc\/mdq439_bb0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"issue":"9538","key":"10.1093\/annonc\/mdq439_bb0020","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(06)69121-6","article-title":"Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis","volume":"368","author":"Bourhis","year":"2006","journal-title":"Lancet"},{"issue":"17","key":"10.1093\/annonc\/mdq439_bb0025","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa071028","article-title":"Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer","volume":"357","author":"Vermorken","year":"2007","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1093\/annonc\/mdq439_bb0030","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/cncr.20998","article-title":"Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years","volume":"103","author":"Shiboski","year":"2005","journal-title":"Cancer"},{"issue":"6","key":"10.1093\/annonc\/mdq439_bb0035","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.hoc.2008.10.002","article-title":"Human papillomavirus in HNSCC: a European epidemiologic perspective","volume":"22","author":"Licitra","year":"2008","journal-title":"Hematol Oncol Clin North Am"},{"issue":"6","key":"10.1093\/annonc\/mdq439_bb0040","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers","volume":"100","author":"Gillison","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"10.1093\/annonc\/mdq439_bb0045","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/sj.onc.1205214","article-title":"Involvement of intact HPV16 E6\/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control","volume":"21","author":"Wiest","year":"2002","journal-title":"Oncogene"},{"issue":"5","key":"10.1093\/annonc\/mdq439_bb0050","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/ijc.2910360510","article-title":"Papillomavirus DNA in human tongue carcinomas","volume":"36","author":"de Villiers","year":"1985","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1093\/annonc\/mdq439_bb0055","first-page":"567","article-title":"Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence","volume":"5","author":"Franceschi","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"10.1093\/annonc\/mdq439_bb0060","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/(SICI)1097-0215(19960516)66:4<464::AID-IJC9>3.0.CO;2-U","article-title":"Prevalence of mucosotropic human papillomaviruses in squamous-cell carcinoma of the head and neck","volume":"66","author":"Snijders","year":"1996","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1093\/annonc\/mdq439_bb0065","first-page":"567","article-title":"Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence","volume":"5","author":"Franceschi","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"10.1093\/annonc\/mdq439_bb0070","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1200\/JCO.2004.00.3335","article-title":"Molecular classification identifies a subset of human papillomavirus\u2013associated oropharyngeal cancers with favorable prognosis","volume":"24","author":"Weinberger","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdq439_bb0075","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/annonc\/mdq210","article-title":"p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters","volume":"21","author":"Fischer","year":"2010","journal-title":"Ann Oncol"},{"issue":"9","key":"10.1093\/annonc\/mdq439_bb0080","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/cncr.25033","article-title":"Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience","volume":"116","author":"Singhi","year":"2010","journal-title":"Cancer"},{"issue":"1","key":"10.1093\/annonc\/mdq439_bb0085","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1093\/annonc\/mdq439_bb0090","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/ijc.22980","article-title":"A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen","volume":"121","author":"Smeets","year":"2007","journal-title":"Int J Cancer"},{"issue":"12","key":"10.1093\/annonc\/mdq439_bb0095","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1200\/JCO.2008.20.2853","article-title":"Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck","volume":"27","author":"Lassen","year":"2009","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1093\/annonc\/mdq439_bb0100","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1002\/lary.20533","article-title":"Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas","volume":"119","author":"Sedaghat","year":"2009","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1093\/annonc\/mdq439_bb0105","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/ijc.24842","article-title":"Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?","volume":"126","author":"Fischer","year":"2010","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1093\/annonc\/mdq439_bb0110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"10.1093\/annonc\/mdq439_bb0115","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.radonc.2010.02.001","article-title":"HPV and high-risk gene expression profiles predict response to chemoradiotherapy in head and neck cancer, independent of clinical factors","volume":"95","author":"de Jong","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1093\/annonc\/mdq439_bb0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1359-6349(09)72054-3","article-title":"HPV-associated p16-expression and response to radiobiological modifications of radiotherapy in head and neck cancer: results from the randomised DAHANCA trials","author":"Lassen","year":"2009","journal-title":"Euro J Cancer Suppl 7"},{"key":"10.1093\/annonc\/mdq439_bb0125","unstructured":"Nguyen-Tan P, Pajak TF, Wheeler R, et al. A phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas (RTOG 0129): report of efficacy and toxicity. Proceedings of the Multidisciplinary Head and Neck Cancer Symposium. ECCO ESMO 2010 Berlin, Chandler Arizona, February 25\u201327 (Abstr). 2010."}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419395912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419395912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/21\/10\/1931\/909093\/mdq439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T17:40:44Z","timestamp":1711734044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419395912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0923753419395912"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdq439","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}