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Both in case of serendipitous observations and systematic mechanistic explorations, confirmation of new indications for a drug requires hypothesis building around relevant drug-related data, such as molecular targets involved, and patient and cellular responses. These datasets are available in public repositories, but apart from sifting through the sheer amount of data imposing computational bottleneck, a major challenge is the difficulty in selecting which databases to use from an increasingly large number of available databases. The database selection is made harder by the lack of an overview of the types of data offered in each database. In order to alleviate these problems and to guide the end user through the drug repurposing efforts, we provide here a survey of 102 of the most promising and drug-relevant databases reported to date. We summarize the target coverage and types of data available in each database and provide several examples of how multi-database exploration can facilitate drug repurposing.<\/jats:p>","DOI":"10.1093\/bib\/bbaa003","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T12:11:51Z","timestamp":1579781511000},"page":"1656-1678","source":"Crossref","is-referenced-by-count":113,"title":["Exploration of databases and methods supporting drug repurposing: a comprehensive survey"],"prefix":"10.1093","volume":"22","author":[{"given":"Ziaurrehman","family":"Tanoli","sequence":"first","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland"}]},{"given":"Umair","family":"Seemab","sequence":"additional","affiliation":[{"name":"Haartman Institute, University of Helsinki, Finland"}]},{"given":"Andreas","family":"Scherer","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland"}]},{"given":"Krister","family":"Wennerberg","sequence":"additional","affiliation":[{"name":"Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Denmark"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Faculty of medicine, University of Helsinki, Finland"}]},{"given":"Markus","family":"V\u00e4h\u00e4-Koskela","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland"}]}],"member":"286","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"key":"2021032314162536800_ref1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.1099480","article-title":"Overriding imatinib resistance with a novel ABL kinase inhibitor","volume":"305","author":"Shah","year":"2004","journal-title":"Science"},{"key":"2021032314162536800_ref2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd3078","article-title":"How to improve R&D productivity: the pharmaceutical industry\u2019s grand challenge","volume":"9","author":"Paul","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"2021032314162536800_ref3","first-page":"172","article-title":"The cost of new drug discovery and development","volume":"4","author":"Dickson","year":"2009","journal-title":"Discov Med"},{"key":"2021032314162536800_ref4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/joim.12590","article-title":"Modern multiple myeloma therapy: deep, sustained treatment response and good clinical outcomes","volume":"281","author":"Landgren","year":"2017","journal-title":"J Intern Med"},{"key":"2021032314162536800_ref5","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM198012183032516","article-title":"Reversal of baldness in patient receiving minoxidil for hypertension","volume":"303","author":"Zappacosta","year":"1980","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"2021032314162536800_ref6","first-page":"28","article-title":"Treatment of inoperable gastrointestinal stromal tumor (GIST) with Imatinib (Glivec, Gleevec)","volume":"97","author":"Joensuu","year":"2002","journal-title":"Med Klin (Munich)"},{"key":"2021032314162536800_ref7","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.drudis.2015.05.001","article-title":"Drug repositioning and repurposing: terminology and definitions in literature","volume":"20","author":"Langedijk","year":"2015","journal-title":"Drug Discov Today"},{"key":"2021032314162536800_ref8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1464-410X.1996.10220.x","article-title":"Sildenafil, a novel effective oral therapy for male erectile dysfunction","volume":"78","author":"Boolell","year":"1996","journal-title":"Br J Urol"},{"key":"2021032314162536800_ref9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tips.2013.06.005","article-title":"Cancer drug discovery by repurposing: teaching new tricks to old dogs","volume":"34","author":"Gupta","year":"2013","journal-title":"Trends Pharmacol Sci"},{"key":"2021032314162536800_ref10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.biopha.2018.11.127","article-title":"An update on drug repurposing: re-written saga of the drug\u2019s fate. 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