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To date, a chemical compound, dimethyl sulfate (DMS), has been developed to probe the RNA structure at the transcriptome level effectively. We proposed a database, RSVdb (https:\/\/taolab.nwafu.edu.cn\/rsvdb\/), for the browsing and visualization of transcriptome RNA structures. RSVdb, including 626\u00a0225 RNAs with validated DMS reactivity from 178 samples in eight species, supports four main functions: information retrieval, research overview, structure prediction and resource download. Users can search for species, studies, transcripts and genes of interest; browse the quality control of sequencing data and statistical charts of RNA structure information; preview and perform online prediction of RNA structures in silico and under DMS restraint of different experimental treatments and download RNA structure data for species and studies. Together, RSVdb provides a reference for RNA structure and will support future research on the function of RNA structure at the transcriptome level.<\/jats:p>","DOI":"10.1093\/bib\/bbaa071","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T15:10:28Z","timestamp":1586358628000},"source":"Crossref","is-referenced-by-count":5,"title":["RSVdb: a comprehensive database of transcriptome RNA 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